Analytical Data
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Gene name
TRPV3
- Application
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Alternative Names
VRL3; Vanilloid receptor-like 3
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q8NET8
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Expression Region
Asn671~Val790
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Molecular Weight
18kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TRPV3 (Transient Receptor Potential Vanilloid 3) is a member of the TRP channel family that has garnered significant attention due to its role in sensing temperature and mediating pain perception. It is primarily expressed in keratinocytes, which are the predominant cell type in the epidermis, and is implicated in various physiological processes, including thermosensation, inflammation, and skin-related pathologies. The activation of TRPV3 by heat or specific chemical ligands leads to an influx of cations, triggering cellular responses that can influence pain signaling and sensory processing. Research on recombinant TRPV3 proteins aims to elucidate the structure-function relationships of this channel, providing insights into its ion permeability, regulatory mechanisms, and potential therapeutic targets for pain management and dermatological disorders. Understanding the molecular mechanisms underlying TRPV3 activation and its downstream signaling pathways can pave the way for the development of novel analgesics and treatments for skin diseases, highlighting the importance of TRPV3 in both basic and translational research. This has fueled the demand for recombinant TRPV3 proteins, facilitating studies on its pharmacological properties, interactions with ligands, and potential roles in disease states, thus contributing to a broader understanding of sensory biology and its implications in human health.
