Analytical Data
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基因名
IL-27R alpha/TCCR
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简介
IL-27R alpha(Interleukin 27 receptor alpha) is a subunit of the interleukin-27 receptor, an inflammatory cytokine that possesses extensive immunological functions. IL-27R alphacan be used as a natural IL-27 antagonist[1]. IL-27R alpha/TCCR Protein, Mouse (HEK293, His) is a recombinant protein with a His label that consists of 482 amino acids (G29-K510) and is produced by HEK293 cells.
- Application
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生物活性
Immobilized IL-27 (HY-P72554) at 5 μg/mL (100 μL/well) can bind Biotinylated Mouse IL-27 Ra Protein.The ED50 for this effect is 0.4573 μg/mL. Immobilized IL-27 (HY-P72554) at 5 μg/mL (100 μL/well) can bind Biotinylated Mouse IL-27 Ra Protein.The ED50 for this effect is 0.4573 μg/mL.
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别名
Interleukin-27 receptor subunit alpha; IL-27R-alpha; TCCR; WSX-1; IL-27RA
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种属
Mouse
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表达系统
HEK293
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标签
C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O70394
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表达区间
G29-K510
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蛋白长度
Partial
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分子量
54.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IL-27R alpha, also known as TCCR (IL-27 receptor alpha), is a key component of the interleukin-27 (IL-27) signaling pathway, which plays a critical role in immune regulation and inflammation. IL-27 is a member of the IL-6 cytokine family, produced primarily by dendritic cells and macrophages, and is known for its ability to influence the differentiation and function of various immune cells, including T cells and B cells. The IL-27R alpha chain is responsible for binding to IL-27, initiating downstream signaling that can modulate immune responses, promote the development of regulatory T cells, and enhance the antiviral and antitumor activities of immune cells. Research into the IL-27R alpha/TCCR recombinant protein has gained momentum due to its potential therapeutic applications in autoimmune diseases, cancer, and chronic inflammatory conditions. By understanding the structural and functional properties of this receptor, scientists aim to develop innovative treatments that can either enhance or inhibit its signaling pathways, thus manipulating immune responses for clinical benefit. Furthermore, the recombinant protein serves as a valuable tool for studying IL-27 signaling mechanisms and identifying biomarkers for diseases influenced by this pathway, paving the way for novel therapeutic interventions in the field of immunology and oncology.
