Analytical Data
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基因名
VKOR1
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简介
As the catalytic subunit of the VKOR complex, the VKOR1 protein is crucial in vitamin K metabolism and is essential for the reduction of inactive vitamin K 2,3-epoxide to the active form. This process is critical for γ-carboxylation of proteins and is particularly important for blood coagulation and the synthesis of coagulation factors. VKOR1 Protein, Human (HEK293, GFP, His) is the recombinant human-derived VKOR1 protein, expressed by HEK293 , with C-10*His, GFP labeled tag.
- Application
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别名
VKORC1; Vitamin K epoxide reductase complex subunit 1; Vitamin K1 2; 3-epoxide reductase subunit 1
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种属
Human
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表达系统
HEK293
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标签
C-10*His;GFP
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BQB6
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表达区间
M1-H163
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蛋白长度
Full Length
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
VKOR1 (Vitamin K Epoxide Reductase 1) plays a crucial role in the vitamin K cycle, facilitating the regeneration of reduced vitamin K, which is essential for the post-translational modification of several proteins involved in blood coagulation. The enzyme's dysfunction can lead to various coagulation disorders and has been implicated in resistance to anticoagulant medications such as warfarin. As a result, understanding VKOR1 at the molecular level is vital for advancing therapeutic strategies in managing coagulation-related diseases. The recombinant expression of VKOR1 in various systems, such as bacteria, yeast, or mammalian cells, allows researchers to obtain the protein in sufficient quantities for biochemical and structural studies. These studies aim to elucidate the enzyme's mechanism of action, identify key residues involved in its function, and assess its interaction with vitamin K and anticoagulants. Furthermore, recombinant VKOR1 serves as a valuable tool for drug screening and the design of novel anticoagulants with improved specificity and reduced side effects. Overall, the research on VKOR1 recombinant proteins holds significant promise for enhancing our understanding of coagulation processes and developing better therapeutic options for patients with coagulation disorders.
