Analytical Data
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基因名
BRDT
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简介
The BRDT protein is a testis-specific chromatin factor that is essential for acetylated histones and specifically recognizes H4K5ac and H4K8ac. It plays a key role in spermatogenesis by promoting gene activation at specific developmental stages in late pachytene spermatocytes. BRDT Protein, Human (His, SUMO) is the recombinant human-derived BRDT protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
- Application
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别名
BRDT; Bromodomain testis-specific protein; Cancer/testis antigen 9; CT9; RING3-like protein
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种属
Human
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表达系统
E. coli
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标签
N-6*His;N-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q58F21
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表达区间
N21-E137
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蛋白长度
Partial
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BRDT, a member of the bromodomain and extraterminal (BET) family, has garnered significant attention in recent years due to its pivotal role in the regulation of gene expression through chromatin remodeling and transcriptional regulation. Initially identified in mouse testis, BRDT is crucial for spermatogenesis, suggesting its importance in reproduction. Studies have shown that BRDT interacts with acetylated histones, influencing the transcriptional activity of numerous genes involved in germ cell development. Beyond reproductive biology, BRDT has emerged as a potential target in cancer therapy, as its overexpression has been linked to various malignancies. Understanding the structure and function of BRDT at the molecular level is essential for developing therapeutic strategies aimed at modulating its activity. Recent advancements in protein engineering have enabled the production of recombinant BRDT, allowing for detailed analysis of its functional domains and interactions. This research not only enhances our understanding of BRDT's biological roles but also opens avenues for innovative treatments targeting BET proteins in disease contexts. Overall, BRDT represents a fascinating area of study, bridging reproductive biology and cancer research, and offers promising prospects for therapeutic interventions through targeted modulation of its activity.
