Analytical Data
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基因名
KBTBD6
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简介
KBTBD6 is a key member of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex, acting as a substrate adapter to coordinate the “Lys-48” ubiquitination and subsequent proteasomal degradation of the RAC1 guanine exchange factor TIAM1. This regulatory role enables KBTBD6 to control RAC1 signaling, affecting important processes such as cytoskeletal organization, cell migration, and cell proliferation. KBTBD6 Protein, Human (sf9) is the recombinant human-derived KBTBD6 protein, expressed by sf9 insect cells , with tag free.
- Application
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别名
KBTBD6; Kelch repeat and BTB domain-containing protein 6
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种属
Human
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表达系统
Baculovirus
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q86V97
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表达区间
Q2-Q674
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蛋白长度
Partial
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KBTBD6 is a member of the Kelch repeat and BTB (BR-C, TTC, and C-terminal) domain-containing protein family, which plays significant roles in various cellular processes including protein degradation and signal transduction. Recent research has highlighted the importance of KBTBD6 in regulating cellular functions through its involvement in the ubiquitin-proteasome pathway, where it acts as an E3 ubiquitin ligase. Dysregulation of KBTBD6 has been associated with several diseases, including cancer and neurodegenerative disorders, making it an attractive target for therapeutic intervention. The study of KBTBD6 recombinant proteins allows for a deeper understanding of its structure-function relationship and interactions with other cellular components, facilitating the elucidation of its role in disease mechanisms. Additionally, the exploration of KBTBD6 may provide insights into novel drug development strategies aimed at modulating its activity for therapeutic benefits. Overall, the investigation of KBTBD6 recombinant proteins is crucial for advancing our knowledge of cellular regulation and its implications for health and disease.
