Analytical Data
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基因名
Apolipoprotein H/APOH
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简介
Apolipoprotein H/APOH proteins have multiple functions and can bind to negatively charged substances such as heparin and phospholipids. Its diverse interactions highlight the adaptability that is critical for preventing activation of the intrinsic coagulation cascade by binding to phospholipids on the surface of damaged cells. Apolipoprotein H/APOH Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Apolipoprotein H/APOH protein, expressed by HEK293 , with C-His labeled tag.
- Application
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别名
Apo-H; B2GP1; B2G1; APOH; B2GPI; beta(2)GPI; BG; β(2)GPI;
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种属
Cynomolgus
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表达系统
HEK293
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标签
C-8*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
XP_045230479.1
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表达区间
G20-C345
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蛋白长度
Partial
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分子量
50-65 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Apolipoprotein H (APOH), also known as beta-2-glycoprotein I, is a pivotal protein in lipid metabolism and plays a crucial role in the regulation of coagulation processes. It is primarily synthesized in the liver and is associated with various lipoprotein particles, influencing their function and stability in the circulatory system. Recent research has highlighted the significance of APOH in autoimmune diseases, particularly antiphospholipid syndrome, where its autoantibodies can lead to increased thrombosis risk. Additionally, APOH has been implicated in the clearance of apoptotic cells and immune responses, making it a subject of interest in both cardiovascular and autoimmune pathologies. The recombinant production of APOH has emerged as a valuable tool for further investigations into its physiological and pathophysiological roles. By utilizing recombinant techniques, researchers can generate large quantities of pure protein, facilitating biochemical studies, structural analyses, and the development of therapeutic applications. Investigating the properties and functions of recombinant APOH not only aids in understanding its biological mechanisms but also holds potential for creating novel diagnostic markers and therapeutic agents for diseases where APOH is implicated. This line of research represents a significant intersection of molecular biology and clinical applications, offering prospects for enhancing disease management and understanding the underlying mechanisms of lipid metabolism and its related disorders.
