Analytical Data
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Gene name
IPP
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简介
IPP may organize the actin cytoskeleton, affecting the structural arrangement and dynamics of the cell's cytoskeletal network. It contributes to the organization of actin filaments, which is critical for cell morphology, movement and signaling. IPP Protein, Human (sf9, His, Strep) is the recombinant human-derived IPP protein, expressed by sf9 insect cells , with N-Strep, N-8*His labeled tag.
- Application
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Alternative Names
IPP; Actin-binding protein IPP; Intracisternal A particle-promoted polypeptide; IPP; Kelch-like protein 27
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Species
Human
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Source
Baculovirus
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Tag
N-StrepⅡ;N-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y573
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Expression Region
A2-L584
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of IPP (isoprenyl pyrophosphate) recombinant proteins has gained significant attention due to their key role in various biological processes, including cell signaling, protein modification, and lipid metabolism. Isoprenoids, a diverse class of organic compounds, are essential for the post-translational modification of proteins, particularly through farnesylation and geranylgeranylation mechanisms. These modifications are critical for protein function, influencing processes such as membrane localization, protein-protein interactions, and signal transduction pathways. Disruptions in isoprenoid metabolism have been linked to diseases, including cancer and cardiovascular diseases, making the understanding of IPP biology increasingly important. The advent of recombinant DNA technology allows for the generation of IPP proteins in a controlled manner, enabling researchers to investigate their structure-function relationships and molecular mechanisms in depth. Furthermore, recombinant expression systems facilitate the production of tagged or modified versions of IPP proteins, providing tools for biophysical analyses, enzymatic assays, and therapeutic applications. As such, the exploration of IPP recombinant proteins not only sheds light on fundamental cellular processes but also holds potential for novel biotechnological and pharmaceutical advancements.
