Analytical Data
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基因名
TRPA1
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简介
The TRPA1 protein is a receptor-activated nonselective cation channel that is critical for pain detection and may affect cold sensation, oxygen sensing, cough reflex, itch, and inner ear function. It responds to inflammatory mediators and irritants such as allyl thiocyanate (AITC), cinnamic aldehyde, diallyl disulfide (DADS), and acrolein. TRPA1 Protein, Human (HEK293, His, MBP, FLAG) is the recombinant human-derived TRPA1 protein, expressed by HEK293 , with N-10*His, N-MBP, C-Flag labeled tag.
- Application
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别名
TRPA1; Transient receptor potential cation channel subfamily A member 1; Ankyrin-like with transmembrane domains protein 1; Transformation-sensitive protein p120; Wasabi receptor
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种属
Human
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表达系统
HEK293
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标签
N-MBP;C-Flag;N-10*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O75762
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表达区间
K2-P1119
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蛋白长度
Full Length
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Transient Receptor Potential A1 (TRPA1) is a cation channel primarily expressed in sensory neurons and plays a crucial role in nociception and thermosensation. It is activated by various stimuli, including environmental irritants, harmful substances, and temperature extremes, making it a key player in pain perception and inflammatory responses. Due to its involvement in pain mechanisms, TRPA1 has garnered significant interest in the field of pain research and pharmacology, with the potential for therapeutic interventions targeting this channel. The recombinant expression of TRPA1 allows for detailed investigation of its biophysical properties, activation mechanisms, and pharmacological modulation. Research into TRPA1 has been propelled by advances in molecular biology techniques, enabling the production of functional TRPA1 proteins for in vitro studies. These recombinant proteins facilitate high-throughput screening of novel analgesics and contribute to a deeper understanding of TRPA1's role in pathological conditions associated with chronic pain, neuropathy, and inflammatory diseases. Overall, the study of TRPA1 recombinant proteins holds promise for developing targeted strategies to alleviate pain and improve patient outcomes in various pain-related disorders.
