Analytical Data
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基因名
Semaphorin-4B/SEMA4B
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简介
Semaphorin-4B (SEMA4B) protein inhibits axonal extension by emitting local signals that define inaccessible territories for growing axons.It interacts with the GIPC PDZ domain, regulating axonal guidance and territorial specificity during neural development.Semaphorin-4B/SEMA4B Protein, Mouse (HEK293, His) is the recombinant mouse-derived Semaphorin-4B/SEMA4B protein, expressed by HEK293 , with C-His labeled tag.
- Application
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别名
Semaphorin-4B; Semaphorin-C; SEMA4B; KIAA1745; SEMAC; MGC131831; SemC
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种属
Mouse
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表达系统
HEK293
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标签
C-8*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q62179
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表达区间
L31-E703
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蛋白长度
Extracellular Domain
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分子量
78-83 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Semaphorin-4B (SEMA4B) is a member of the semaphorin family, which plays a crucial role in neuronal development and axon guidance, as well as in the regulation of immune responses and cancer progression. Research has shown that SEMA4B interacts with various receptors, such as Plexin-B1 and Neuropilin-1, influencing cellular signaling pathways that are pivotal for cell migration, differentiation, and apoptosis. Notably, SEMA4B is implicated in several pathological conditions, including autoimmune diseases and malignancies, making it a target of interest for therapeutic interventions. The creation of recombinant SEMA4B proteins has enabled researchers to study its functional effects in vitro and in vivo, providing insights into its biological mechanisms and potential as a biomarker or therapeutic agent. Investigating the structure-function relationship of SEMA4B through recombinant protein studies can further elucidate its role in the tumor microenvironment and immune modulation, highlighting its relevance in both neuroscience and immunology. Overall, the exploration of SEMA4B offers promising avenues for understanding complex biological interactions and developing novel strategies for disease management.
