Analytical Data
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Gene name
BMP-5
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简介
Bone morphogenetic protein 5 (BMP-5) is a pleiotropic ligand protein belonging to the TGFβ family, which is mainly expressed in the lung and liver. After BMP-5 silencing, the activity of p38/ERK signaling pathway can be down-regulated to inhibit chondrocyte senescence and apoptosis and knee arthritis (OA)[1]. Bmp-5 initiates typical BMP signaling cascades by binding to type I receptor BMPR1A and type II receptor BMPR2[2], or triggers signals through atypical pathways such as MAPK p38 signaling cascades to promote chondrogenic differentiation[3].
- Application
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Alternative Names
Bone morphogenetic protein 5; BMP-5
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Species
Human
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Source
HEK293
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Tag
N-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
NP_066551.1
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Expression Region
Q324-H454
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Protein Length
Partial
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Molecular Weight
50-55 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Bone morphogenetic protein 5 (BMP-5) is a member of the BMP family, which plays a critical role in skeletal development, bone formation, and tissue regeneration. Initially identified for its ability to induce bone formation in ectopic sites, BMP-5 has garnered significant interest for its regulatory functions in various biological processes, including chondrogenesis, angiogenesis, and the maintenance of neuronal health. The exploration of BMP-5's molecular pathways has led to its potential applications in regenerative medicine and orthopedics, yet our understanding of its specific mechanisms and interactions remains incomplete. Recent studies have focused on the recombinant production of BMP-5 to investigate its therapeutic potential and to address challenges associated with its clinical application. By utilizing advanced biotechnological techniques, researchers aim to produce high-yield, biologically active BMP-5 proteins to facilitate studies on its effects in vitro and in vivo. Investigating the role of BMP-5 in cellular signaling pathways, as well as its interactions with other growth factors, is essential for developing targeted therapies for conditions such as osteoporosis, cartilage injuries, and neurodegenerative diseases. Continued research on BMP-5 recombinant proteins thus holds promise for uncovering novel strategies for enhancing tissue repair and regeneration in various clinical contexts.
