Analytical Data
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基因名
BMP-5
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简介
Bone morphogenetic protein 5 (BMP-5) is a pleiotropic ligand protein belonging to the TGFβ family, which is mainly expressed in the lung and liver. After BMP-5 silencing, the activity of p38/ERK signaling pathway can be down-regulated to inhibit chondrocyte senescence and apoptosis and knee arthritis (OA)[1]. Bmp-5 initiates typical BMP signaling cascades by binding to type I receptor BMPR1A and type II receptor BMPR2[2], or triggers signals through atypical pathways such as MAPK p38 signaling cascades to promote chondrogenic differentiation[3].
- Application
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别名
Bone morphogenetic protein 5; BMP-5
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种属
Human
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表达系统
HEK293
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标签
N-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
NP_066551.1
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表达区间
Q324-H454
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蛋白长度
Partial
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分子量
50-55 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Bone morphogenetic protein 5 (BMP-5) is a member of the BMP family, which plays a critical role in skeletal development, bone formation, and tissue regeneration. Initially identified for its ability to induce bone formation in ectopic sites, BMP-5 has garnered significant interest for its regulatory functions in various biological processes, including chondrogenesis, angiogenesis, and the maintenance of neuronal health. The exploration of BMP-5's molecular pathways has led to its potential applications in regenerative medicine and orthopedics, yet our understanding of its specific mechanisms and interactions remains incomplete. Recent studies have focused on the recombinant production of BMP-5 to investigate its therapeutic potential and to address challenges associated with its clinical application. By utilizing advanced biotechnological techniques, researchers aim to produce high-yield, biologically active BMP-5 proteins to facilitate studies on its effects in vitro and in vivo. Investigating the role of BMP-5 in cellular signaling pathways, as well as its interactions with other growth factors, is essential for developing targeted therapies for conditions such as osteoporosis, cartilage injuries, and neurodegenerative diseases. Continued research on BMP-5 recombinant proteins thus holds promise for uncovering novel strategies for enhancing tissue repair and regeneration in various clinical contexts.
