Analytical Data
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基因名
TMED4
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简介
The TMED4 protein is complexly involved in vesicular protein trafficking in the early secretory pathway, which is critical for targeting and maintenance of the Golgi apparatus. Its involvement extends to the biosynthesis of secretions, emphasizing its role in processing. TMED4 Protein, Human (HEK293, Fc) is the recombinant human-derived TMED4 protein, expressed by HEK293 , with C-mFc labeled tag.
- Application
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别名
Transmembrane emp24 domain-containing protein 4; ERS25; GMP25iso; p24alpha3
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种属
Human
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表达系统
HEK293
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标签
C-mFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q7Z7H5-1
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表达区间
L30-R194
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蛋白长度
Lumenal Domain
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分子量
45.6 kDa.
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TMED4, also known as transmembrane emp24-like protein 4, is a member of the TMED protein family, which is implicated in the process of protein transportation within the secretory pathway. Research into TMED4 has gained traction due to its potential roles in various cellular processes, including protein sorting, glycoprotein maturation, and involvement in disease mechanisms, particularly within cancer biology. The protein is believed to facilitate the formation of transport vesicles from the endoplasmic reticulum (ER) to the Golgi apparatus, playing a crucial role in maintaining cellular homeostasis. Aberrant expression of TMED4 has been associated with tumorigenesis and metastasis, making it an interesting target for therapeutic strategies. Understanding the structure-function relationship of TMED4 and its interactions with other cellular components is vital for elucidating its biological significance. As the role of TMED4 in disease continues to unfold, the development of recombinant TMED4 proteins for research purposes holds promise for advancing our knowledge. Such studies could improve our understanding of cargo loading and intracellular trafficking, leading to innovative approaches for the treatment of diseases linked to protein misfolding and trafficking disorders. Thus, the study of recombinant TMED4 not only contributes to fundamental science but also has potential translational implications, paving the way for targeted molecular therapies in oncological and other contexts.
