Analytical Data
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Gene name
TMED4
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简介
The TMED4 protein is complexly involved in vesicular protein trafficking in the early secretory pathway, which is critical for targeting and maintenance of the Golgi apparatus. Its involvement extends to the biosynthesis of secretions, emphasizing its role in processing. TMED4 Protein, Human (HEK293, Fc) is the recombinant human-derived TMED4 protein, expressed by HEK293 , with C-mFc labeled tag.
- Application
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Alternative Names
Transmembrane emp24 domain-containing protein 4; ERS25; GMP25iso; p24alpha3
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Species
Human
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Source
HEK293
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Tag
C-mFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q7Z7H5-1
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Expression Region
L30-R194
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Protein Length
Lumenal Domain
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Molecular Weight
45.6 kDa.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TMED4, also known as transmembrane emp24-like protein 4, is a member of the TMED protein family, which is implicated in the process of protein transportation within the secretory pathway. Research into TMED4 has gained traction due to its potential roles in various cellular processes, including protein sorting, glycoprotein maturation, and involvement in disease mechanisms, particularly within cancer biology. The protein is believed to facilitate the formation of transport vesicles from the endoplasmic reticulum (ER) to the Golgi apparatus, playing a crucial role in maintaining cellular homeostasis. Aberrant expression of TMED4 has been associated with tumorigenesis and metastasis, making it an interesting target for therapeutic strategies. Understanding the structure-function relationship of TMED4 and its interactions with other cellular components is vital for elucidating its biological significance. As the role of TMED4 in disease continues to unfold, the development of recombinant TMED4 proteins for research purposes holds promise for advancing our knowledge. Such studies could improve our understanding of cargo loading and intracellular trafficking, leading to innovative approaches for the treatment of diseases linked to protein misfolding and trafficking disorders. Thus, the study of recombinant TMED4 not only contributes to fundamental science but also has potential translational implications, paving the way for targeted molecular therapies in oncological and other contexts.
