Analytical Data
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Gene name
Pepsinogen C/PGC
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简介
Pepsinogen C/PGC protein hydrolyzes various proteins, playing a crucial role in digestion by breaking them down into smaller peptides. Its proficiency in protein hydrolysis contributes to the initial stages of digestion, making it vital in the overall digestive cascade. Pepsinogen C/PGC Protein, Human (His) is the recombinant human-derived Pepsinogen C/PGC protein, expressed by E. coli , with N-His labeled tag.
- Application
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Alternative Names
Gastricsin; Pepsinogen C; PGC; PEPC
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P20142-1
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Expression Region
I153-I239
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Protein Length
Partial
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Molecular Weight
10 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Pepsinogen C (PGC) is an important precursor of pepsin, an enzyme that plays a crucial role in protein digestion in the stomach. The study of PGC has garnered significant interest due to its potential implications in both digestive health and various pathological conditions, including gastrointestinal disorders and certain cancers. PGC exists in several isoforms, influenced by genetic variations and environmental factors. Recombinant PGC production allows researchers to investigate its structure-function relationships, enzymatic activity, and regulatory mechanisms in greater detail. Advances in molecular biology techniques have enabled the successful expression of recombinant PGC in various host systems, facilitating the assessment of its functional properties and interactions with other biochemical pathways. Furthermore, understanding the role of PGC in the digestive system can aid in identifying novel therapeutic targets for metabolic diseases. As a result, research on recombinant PGC is not only essential for fundamental biochemical knowledge but also for its potential applications in clinical settings, including diagnostic markers and targeted treatments for digestive disorders.
