Analytical Data
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Gene name
NAA10/ARD1
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简介
The NAA10/ARD1 protein is the catalytic subunit of the N-terminal acetyltransferase complex and has alpha acetyltransferase activity. NAA10/ARD1 affects vascular, hematopoietic, and neuronal growth and development. NAA10/ARD1 inhibits tumor cell migration, inhibits mTOR activity and cancer development. NAA10/ARD1 Protein, Human (sf9, His-GST) is the recombinant human-derived NAA10/ARD1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
- Application
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Alternative Names
N-alpha-acetyltransferase 10; hARD1; NatA catalytic subunit Naa10; ARD1; ARD1A; TE2
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Species
Human
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Source
Baculovirus
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Tag
N-His;N-GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P41227
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Expression Region
M1-S235
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Protein Length
Full Length
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Molecular Weight
49 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NAA10, also known as ARD1 (N-alpha-acetyltransferase 10), is a pivotal enzyme involved in the N-terminal acetylation of proteins, a crucial post-translational modification that influences various cellular processes, including protein stability, localization, and interactions. The study of NAA10/ARD1 has gained attention due to its role in multiple biological functions and its implications in human health and disease. Notably, mutations in the NAA10 gene are linked to syndromes such as Pasqualini syndrome, characterized by developmental defects and intellectual disability. Research has increasingly focused on understanding the biochemical mechanisms of NAA10/ARD1 in both normal physiology and pathological conditions, highlighting its involvement in cancer progression and cellular stress responses. Recombination and expression of NAA10/ARD1 proteins in model systems facilitate investigations into their functional roles, revealing how acetylation affects protein dynamics and cellular signaling pathways. The exploration of NAA10/ARD1 provides insights into fundamental cellular mechanisms and has potential therapeutic implications, paving the way for targeted strategies in treating related disorders.
