Analytical Data
-
Gene name
Syntaxin-BP1
-
简介
Syntaxin-BP1 protein critically regulates synaptic vesicle docking and fusion, binds GTP-binding proteins and ensures efficient neurotransmission. It interacts with syntaxin in a 1:1 ratio and shows specificity for syntaxin 1, 2, and 3 (excluding syntaxin 4). Syntaxin-BP1 Protein, Human (sf9, His-GST) is the recombinant human-derived Syntaxin-BP1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
- Application
-
Alternative Names
Syntaxin-binding protein 1; MUNC18-1; N-Sec1; UNC18A; p67
-
Species
Human
-
Source
Baculovirus
-
Tag
N-His;N-GST
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P61764
-
Expression Region
M1-S594
-
Protein Length
Full Length
-
Molecular Weight
80 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Syntaxin-BP1 (Syn-BP1) is a member of the syntaxin family, primarily recognized for its role in neuron-specific exocytosis and synaptic transmission. Research into the functional properties and interactions of Syn-BP1 has garnered significant interest due to its implications in neuronal communication and various neurological disorders. Syn-BP1 acts as a critical adaptor protein, linking syntaxins to the vesicular trafficking machinery, thereby facilitating the fusion of synaptic vesicles with the presynaptic membrane. Understanding the molecular dynamics of Syn-BP1 can provide insights into the regulation of neurotransmitter release, with potential implications for diseases such as schizophrenia, autism, and neurodegeneration. The recombinant expression of Syn-BP1 allows researchers to investigate its structure and function through biochemical and biophysical assays, enabling the characterization of its interactions with other synaptic proteins. Efforts to elucidate the role of Syn-BP1 in synaptic plasticity and the mechanisms underlying its involvement in synaptic vesicle cycling are ongoing. The study of Syn-BP1 not only enhances our comprehension of synaptic function but also holds promise for the development of therapeutic strategies targeting synaptic dysregulation in various neuropsychiatric conditions.
