Analytical Data
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基因名
LRRTM4
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简介
LRRTM4 protein is crucial for vertebrate nervous system development and maintenance. It exhibits synaptogenic activity, limited to excitatory presynaptic differentiation. LRRTM4 is associated with the AMPAR complex, regulating AMPAR complex function and synaptic processes. Understanding LRRTM4's interactions within the complex could offer insights into its role in synaptic regulation and neural connectivity. LRRTM4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived LRRTM4 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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别名
Leucine-rich repeat transmembrane neuronal protein 4
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种属
Mouse
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表达系统
HEK293
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标签
C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q80XG9-1
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表达区间
Q31-K424
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蛋白长度
Extracellular Domain
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分子量
46.4 kDa.
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LRRTM4 (Leucine-rich repeat transmembrane protein 4) is a member of the leucine-rich repeat family of proteins, which are known to play crucial roles in cell adhesion, signaling, and neural development. The interest in LRRTM4 has grown due to its involvement in synaptic formation and function, suggesting that it may be a key regulator in neurological processes. Abnormalities in LRRTM4 expression have been associated with various neurodevelopmental disorders, including autism spectrum disorders and schizophrenia, underscoring the need to understand its biological functions and mechanisms of action. Recent studies have focused on characterizing the protein's structure and its interactions with other synaptic proteins, aiming to uncover its role in establishing and maintaining synaptic connectivity. Furthermore, recombinant LRRTM4 proteins are being utilized to explore their therapeutic potential in modulating synaptic functions and addressing dysregulation in neurodevelopmental conditions. As research progresses, elucidating the full scope of LRRTM4’s function may contribute significantly to the understanding of cognitive behaviors and the development of targeted interventions for related disorders.
