Analytical Data
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Gene name
LRRTM4
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简介
LRRTM4 protein is crucial for vertebrate nervous system development and maintenance. It exhibits synaptogenic activity, limited to excitatory presynaptic differentiation. LRRTM4 is associated with the AMPAR complex, regulating AMPAR complex function and synaptic processes. Understanding LRRTM4's interactions within the complex could offer insights into its role in synaptic regulation and neural connectivity. LRRTM4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived LRRTM4 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
Leucine-rich repeat transmembrane neuronal protein 4
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Species
Mouse
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Source
HEK293
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q80XG9-1
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Expression Region
Q31-K424
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Protein Length
Extracellular Domain
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Molecular Weight
46.4 kDa.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LRRTM4 (Leucine-rich repeat transmembrane protein 4) is a member of the leucine-rich repeat family of proteins, which are known to play crucial roles in cell adhesion, signaling, and neural development. The interest in LRRTM4 has grown due to its involvement in synaptic formation and function, suggesting that it may be a key regulator in neurological processes. Abnormalities in LRRTM4 expression have been associated with various neurodevelopmental disorders, including autism spectrum disorders and schizophrenia, underscoring the need to understand its biological functions and mechanisms of action. Recent studies have focused on characterizing the protein's structure and its interactions with other synaptic proteins, aiming to uncover its role in establishing and maintaining synaptic connectivity. Furthermore, recombinant LRRTM4 proteins are being utilized to explore their therapeutic potential in modulating synaptic functions and addressing dysregulation in neurodevelopmental conditions. As research progresses, elucidating the full scope of LRRTM4’s function may contribute significantly to the understanding of cognitive behaviors and the development of targeted interventions for related disorders.
