Analytical Data
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基因名
IL-10R beta
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简介
IL-10R beta protein is an IL10 cytokine surface receptor involved in IL10-mediated inflammation and immune regulation, as well as viral defense responses. IL-10R beta Protein, Human (HEK293, His-hFc) is expressed by HEK293 cells and with a His and -hFc tag at the C-terminus[3].
- Application
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生物活性
Immobilized Recombinant Human IL 28 R alpha /IFN lambda R1 at 5 μg/mL (100 μL/well) can bind Biotinylated Recombinant Human IL-10R beta .The ED50 for this effect is 1.967 μg/mL. Immobilized Recombinant Human IL 28 R alpha /IFN lambda R1 at 5 μg/ml (100 μl/well) can bind Biotinylated Recombinant Human IL-10R beta .The ED50 for this effect is 1.967 μg/mL.
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别名
Interleukin-10 receptor subunit beta; IL-10RB; CRF2-4; IL-10R2; CDw210b
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种属
Human
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表达系统
HEK293
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标签
C-hFc;C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q08334
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表达区间
M20-S220
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蛋白长度
Extracellular Domain
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分子量
75-85 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interleukin-10 receptor beta (IL-10Rβ) is a crucial component of the interleukin-10 receptor complex, playing a significant role in mediating the anti-inflammatory effects of IL-10, a key cytokine involved in regulating immune responses. Research on IL-10Rβ has gained attention due to its potential implications in various autoimmune diseases, inflammatory conditions, and even cancer. IL-10 is known for its ability to suppress pro-inflammatory cytokine production, thereby promoting tissue repair and maintaining immune homeostasis. The binding of IL-10 to its receptor activates downstream signaling pathways, primarily through the JAK-STAT pathway, which leads to the transcription of target genes that exert anti-inflammatory effects. However, the exact mechanisms governing IL-10Rβ function and its interactions with IL-10 and other signaling molecules are still not fully understood. The recombinant production of IL-10Rβ has facilitated detailed studies on its structure and function, providing insights into its role in immune regulation. Additionally, understanding the biological activities of IL-10Rβ could open new avenues for therapeutic interventions in diseases characterized by dysregulated immune responses. Overall, the ongoing research on IL-10Rβ is pivotal for developing novel strategies aimed at harnessing the anti-inflammatory properties of IL-10 in clinical settings.
