Analytical Data
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Gene name
ACBD6
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简介
ACBD6 protein selectively binds long-chain acyl-CoA, showing a significant preference for unsaturated C18:1-CoA. Unlike other variants such as unsaturated C20:4-CoA and saturated C16:0-CoA, ACBD6 does not bind to free fatty acids. ACBD6 Protein, Human (sf9, His) is the recombinant human-derived ACBD6 protein, expressed by Sf9 insect cells , with N-His labeled tag.
- Application
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Alternative Names
Acyl-CoA-binding domain-containing protein 6; ACBD6
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Species
Human
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Source
Baculovirus
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BR61
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Expression Region
M1-A282
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Protein Length
Full Length
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Molecular Weight
36 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The ACBD6 protein, a member of the acyl-CoA binding protein family, has garnered interest due to its potential roles in cellular metabolism and pathology. In recent years, research has indicated that ACBD6 is involved in lipid metabolism, suggesting a link to various metabolic disorders, including obesity and diabetes. Its ability to bind acyl-CoA suggests a regulatory function in fatty acid metabolism, influencing the biosynthesis and degradation of lipids. Additionally, ACBD6 has been implicated in cellular signaling pathways, including those affecting inflammation and cell proliferation. Given its involvement in multiple biological processes, understanding the mechanisms of ACBD6 action could offer insights into therapeutic strategies for metabolic diseases and associated conditions. Recent studies have also highlighted its expression patterns in various tissues under physiological and pathological states, pointing towards its potential as a biomarker for metabolic dysfunction. Thus, the exploration of ACBD6 as a recombinant protein has become essential for elucidating its structure-function relationships and provides a foundation for its application in metabolic disease research. As advancements in protein engineering and expression systems continue, the characterization of ACBD6 can facilitate the development of targeted interventions aimed at modulating its activity, opening new avenues for clinical applications in the management of metabolic disorders.
