Analytical Data
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Gene name
TRIP10/CIP4
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简介
TRIP10/CIP4 proteins coordinate cellular dynamics and are critical for insulin-induced GLUT4 translocation and membrane tubulation during endocytosis. Good at lipid binding, especially with phosphatidylinositol 4,5-bisphosphate and phosphatidylserine, promoting membrane invagination. TRIP10/CIP4 Protein, Human (sf9, His) is the recombinant human-derived TRIP10/CIP4 protein, expressed by Sf9 insect cells , with C-His labeled tag.
- Application
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Alternative Names
Cdc42-interacting protein 4; Protein Felic; hSTP; TRIP-10; CIP4; STOT; STP
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Species
Human
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Source
Baculovirus
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q15642
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Expression Region
M1-N545
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Protein Length
Partial
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Molecular Weight
84.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TRIP10/CIP4 (T-cell receptor interacting protein 10/CIP4 homolog) is a member of the BAR domain-containing protein family, which plays a crucial role in various cellular processes, including membrane trafficking, cytoskeletal organization, and cell signaling. Recent studies have indicated that TRIP10/CIP4 is involved in the regulation of cell proliferation, differentiation, and apoptosis, making it a significant focus of research in cancer biology and immunology. Its ability to interact with several signaling molecules and adaptors suggests its potential role in modulating intracellular pathways that affect cell function and survival. Moreover, alterations in TRIP10/CIP4 expression levels have been linked to various diseases, including tumorigenesis and autoimmune disorders. Understanding the molecular mechanisms underlying TRIP10/CIP4 activities may provide insights into disease etiology and novel therapeutic targets. The investigation of this recombinant protein encompasses both its structural and functional properties, enabling researchers to elucidate its biological roles and potential applications in targeted therapies. By employing techniques such as protein purification, crystallography, and functional assays, scientists aim to dissect the intricate pathways influenced by TRIP10/CIP4 and its implications in health and disease.
