Analytical Data
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基因名
SCN2B
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简介
SCN2B protein is a key subunit of voltage-gated sodium channels and plays an important role in regulating channel function by interacting with the pore-forming α subunit. This interaction regulates the flux of sodium ions across the cell membrane, affecting neuronal excitability and action potential propagation. SCN2B Protein, Human (HEK293, Fc) is the recombinant human-derived SCN2B protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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别名
Sodium channel subunit beta-2; SCN2B
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种属
Human
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表达系统
HEK293
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标签
C-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O60939
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表达区间
M30-A159
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蛋白长度
Partial
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分子量
53-57 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SCN2B encodes the beta-2 subunit of voltage-gated sodium channels, which play a crucial role in the excitability of neurons and the propagation of action potentials. Mutations in SCN2B have been linked to various neurological disorders, including epilepsy and autism spectrum disorders, highlighting its importance in neuronal function. Research on SCN2B recombinant proteins allows scientists to study the biophysical properties and functional implications of these channels in detail. By expressing and purifying SCN2B, researchers can investigate how changes in the protein structure impact ion conductance and the modulation of sodium channel activity. Furthermore, these studies can help elucidate the mechanisms underlying SCN2B-related pathologies, paving the way for potential therapeutic strategies. Understanding the role of SCN2B in neuronal signaling is essential not only for basic neuroscience but also for developing interventions for conditions associated with its dysfunction. Thus, exploring SCN2B recombinant proteins presents a valuable opportunity to advance our knowledge of sodium channel biology and its relevance in human health and disease.
