Analytical Data
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Gene name
LTC4S
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简介
LTC4S protein catalyzes the specific binding of leukotriene A4 and reduced glutathione (GSH) to generate leukotriene C4. LTC4S Protein, Human (sf9, His) is the recombinant human-derived LTC4S protein, expressed by Sf9 insect cells , with C-His labeled tag.
- Application
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Alternative Names
Leukotriene C4 synthase; LTC4 synthase; LTC4S
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Species
Human
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Source
Baculovirus
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q16873
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Expression Region
M1-A150
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Protein Length
Full Length
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Molecular Weight
17 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LTC4S (leukotriene C4 synthase) is an important enzyme that plays a crucial role in the biosynthesis of leukotrienes, which are lipid mediators involved in various physiological and pathological processes, including inflammation, asthma, and allergic responses. The study of LTC4S is significant because elevated levels of leukotrienes are associated with several inflammatory diseases, making it a potential target for therapeutic intervention. Understanding the structure and function of LTC4S can provide insights into its enzymatic mechanism and regulatory pathways. In recent years, advancements in recombinant protein technology have enabled researchers to produce and purify large quantities of LTC4S, facilitating detailed biochemical and biophysical studies. This recombinant LTC4S allows for the exploration of its interaction with substrates and inhibitors, as well as its role in leukotriene signaling pathways. By elucidating the enzyme's structure and function, researchers aim to uncover novel therapeutic strategies to modulate its activity, potentially leading to new treatments for conditions like asthma and other inflammatory diseases. As such, the study of recombinant LTC4S holds promise for both basic research and clinical applications in improving our understanding of leukotriene-mediated processes in health and disease.
