Analytical Data
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Gene name
Centrin-2
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简介
Centrin-2 protein plays a critical role in microtubule-organized centromere structure, directing centriole duplication, spindle formation, and regulation of cytokinesis. It ensures genome stability by interacting with CALM1 and CCP110. Centrin-2 Protein, Human (HEK293, His) is the recombinant human-derived Centrin-2 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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Alternative Names
Centrin-2; Caltractin isoform 1; CETN2; CALT; CEN2
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Species
Human
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Source
HEK293
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P41208
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Expression Region
M1-Y172
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Protein Length
Full Length
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Centrin-2 is a crucial protein belonging to the centrin family, which plays a pivotal role in various cellular processes, including cell cycle regulation, ciliary function, and signal transduction. It is primarily expressed in ciliated cells and is implicated in the formation and maintenance of the centrosome and the basal bodies of cilia. Research into Centrin-2 has gained significance due to its involvement in several human diseases, particularly those related to reproductive health and ciliopathies, which are disorders arising from defective cilia function. Understanding its structure and function is essential for elucidating the mechanisms underlying these conditions. Recent advancements in recombinant protein technology have facilitated the production of Centrin-2 in various expression systems, allowing for in-depth biochemical characterization and structural studies. These studies aim to uncover the protein's interactions with other cellular components and its involvement in cellular signaling pathways. Furthermore, recombinant Centrin-2 is being explored for its potential role as a therapeutic target, given its pivotal functions in cell division and disease pathology. Investigating the properties and dynamics of Centrin-2 not only enhances our understanding of cellular biology but also opens avenues for developing novel strategies in treating diseases associated with ciliary dysfunction. As such, the study of Centrin-2 and its recombinant forms stands at the forefront of molecular biology research, with implications that extend to medical science and therapeutic development.
