Analytical Data
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Gene name
Cerberus 1/CER1
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简介
The Cerberus 1/CER1 protein emerges as a cytokine that may be involved in preneural induction and somite formation during embryogenesis, in part through its inhibitory effect on BMP signaling. Its regulatory role extends into gastrulation, where it can influence nodal signaling and contribute to primitive streak formation and patterning. Cerberus 1/CER1 Protein, Human (sf9, His) is the recombinant human-derived Cerberus 1/CER1 protein, expressed by Sf9 insect cells , with C-His labeled tag.
- Application
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Alternative Names
Cerberus; DAN domain family member 4; CER1; DAND4
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Species
Human
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Source
Baculovirus
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O95813
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Expression Region
M1-A267
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Protein Length
Full Length
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Cerberus 1 (CER1) is a member of the Cerberus-DAN family of secreted proteins, which plays a crucial role in embryonic development and tissue homeostasis. Initially discovered in the context of early vertebrate development, CER1 is known to act as an inhibitor of bone morphogenetic proteins (BMPs), thereby regulating key signaling pathways that guide primitive ectoderm and mesoderm formation. Its function as an antagonist to BMP signaling highlights its significance in developmental biology and potential implications in various pathologies, including cancer and tissue repair. Research has indicated that perturbations in CER1 expression can result in developmental abnormalities, suggesting its vital role in maintaining proper cellular signaling. Furthermore, as a potential therapeutic target, CER1's involvement in modulating the stem cell niche and influencing differentiation patterns has garnered interest in regenerative medicine. The study of recombinant CER1 protein aims to elucidate its mechanism of action, exploring its interactions with target receptors and downstream signaling cascades, thereby paving the way for novel therapeutic strategies in regenerative therapies and cancer treatment. Overall, the investigation of CER1 not only enhances our understanding of developmental processes but also opens avenues for innovative biomedical applications.
