Analytical Data
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Gene name
STUB1
- Application
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Alternative Names
CHIP; HSPABP2; NY-CO-7; SDCCAG7; UBOX1; C Terminus Of HSC70-Interacting Protein; CLL-associated antigen KW-8; E3 ubiquitin-protein ligase CHIP
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Species
Mouse
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Source
E. coli
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Tag
N-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q9WUD1
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Expression Region
Met1~Glu186
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Molecular Weight
25kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
STUB1, also known as STUB1 or CHIP (C-terminus of Hsc70-interacting protein), is an E3 ubiquitin ligase that plays a crucial role in protein quality control within cells. It is involved in the regulation of protein homeostasis by mediating the ubiquitination and subsequent degradation of misfolded or damaged proteins through the ubiquitin-proteasome system. Research has highlighted STUB1's significance in various cellular processes, including stress responses, apoptosis, and the protection against neurodegenerative diseases. Mutations or dysregulation of STUB1 have been linked to conditions such as cancer and neurodegeneration, suggesting its vital role in maintaining cellular health. Therefore, the recombinant production of STUB1 protein is of paramount importance for understanding its functional mechanisms, interaction with substrate proteins, and its potential as a therapeutic target. Investigating the properties of STUB1, particularly through the use of recombinant techniques, can provide insights into its role in pathophysiological conditions and open new avenues for drug development aimed at enhancing cellular protein quality control mechanisms.
