Analytical Data
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Gene name
STAT3
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简介
S100A8 consists of calcium and zinc bound S100A8, which plays a critical regulatory role in inflammation and immune responses. As calprotectin, it contributes to leukocyte function, regulates the cytoskeleton, and activates intracellular NADPH oxidase. S100A8 Protein, Human (C-His) is the recombinant human-derived S100A8 protein, expressed by E. coli , with C-6*His labeled tag.
- Application
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Alternative Names
Protein S100-A8; S100A8; Calgranulin-A; Cystic fibrosis antigen; Leukocyte L1 complex light chain; MRP-8
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Species
Human
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Source
E. coli
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Tag
C-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P05109
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Expression Region
M1-E93
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Protein Length
Full Length
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Molecular Weight
13.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Signal transducer and activator of transcription 3 (STAT3) is a critical transcription factor that plays essential roles in various cellular processes, including cell growth, differentiation, and survival. Its aberrant activation is increasingly recognized as a hallmark of numerous human diseases, particularly cancer, where it contributes to tumorigenesis, metastasis, and immune evasion. STAT3 can be activated by various cytokines and growth factors, leading to its dimerization, nuclear translocation, and subsequent transcription of target genes involved in proliferation and anti-apoptotic pathways. Due to its central role in oncogenesis, STAT3 has emerged as a promising target for therapeutic intervention. Research on recombinant STAT3 proteins offers valuable insights into its structure-function relationships, signaling mechanisms, and the development of inhibitors. The expression and purification of recombinant STAT3 allow for detailed biochemical and biophysical characterization, helping to elucidate its regulatory mechanisms. Furthermore, studies using recombinant proteins facilitate the high-throughput screening of small molecules or peptide inhibitors, paving the way for novel cancer therapies aimed at STAT3 modulation. Understanding the dynamics and interactions of STAT3 through these experimental approaches promises to advance the development of targeted therapies and improve treatment strategies against STAT3-associated diseases.
