Analytical Data
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基因名
TGFBR1/ALK-5
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简介
TGFBR1/ALK-5 proteins cooperate with TGFBR2 to form dedicated receptors for TGFB1, TGFB2, and TGFB3, transmitting signals and coordinating different physiological and pathological processes. It induces cell cycle arrest, modulates mesenchymal cell dynamics, contributes to wound healing, and affects immunosuppression and carcinogenesis. TGFBR1/ALK-5 Protein, Human (HEK293, Fc) is the recombinant human-derived TGFBR1/ALK-5 protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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生物活性
Measured by its binding ability in a functional ELISA. When Recombinant Human TGF-beta RII is immobilized at 1 μg/mL (100 μL/well), it binds Recombinant Human TGF-beta RI in the presence of TGF-beta 1. The concentration of rhTGF-beta RI that produces 50% of the optimal binding response is approximately 1.278 μg/mL. Measured by its binding ability in a functional ELISA. When Recombinant Human TGF-beta RII is immobilized at 1 μg/mL (100 μL/well), it binds Recombinant Human TGF-beta RI in the presence of TGF-beta 1. The concentration of rhTGF-beta RI that produces 50% of the optimal binding response is approximately 1.278 μg/mL.
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别名
TGF-beta receptor type-1; ALK-5; SKR4; TbetaR-I; AAT5
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种属
Human
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表达系统
HEK293
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标签
C-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P36897
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表达区间
L34-E125
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蛋白长度
Extracellular Domain
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分子量
40-60 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TGFBR1, also known as TGF-β receptor type I, is a key component of the TGF-β signaling pathway, which plays a crucial role in regulating various physiological processes, including cell growth, differentiation, and apoptosis. Abnormalities in this pathway are implicated in numerous diseases, including cancer, fibrosis, and autoimmune disorders. ALK-5, another designation for TGFBR1, serves as a receptor that transduces the signals initiated by TGF-β ligands. Research into TGFBR1/ALK-5 recombinant proteins has gained significant attention due to their potential therapeutic applications. By creating recombinant forms of this receptor, scientists aim to study its functional properties and signaling mechanisms in greater detail. These studies can help elucidate how TGF-β signaling contributes to disease pathogenesis and may identify novel targets for intervention. Moreover, understanding the structure and dynamics of TGFBR1 can facilitate the design of drugs that specifically modulate its activity, offering hope for tailored treatments in related diseases. Thus, TGFBR1/ALK-5 recombinant proteins represent a valuable tool in biomedical research, advancing our knowledge of TGF-β signaling and its impact on human health.
