Analytical Data
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基因名
Syntaxin-3
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简介
Syntaxin-3 protein plays a potentially critical role in docking synaptic vesicles at the presynaptic zone, suggesting a role in regulating neurotransmitter release. Furthermore, it is also implicated as an apical receptor in apical vesicle membrane fusion, suggesting a broader involvement in intracellular trafficking. Syntaxin-3 Protein, Human (His) is the recombinant human-derived Syntaxin-3 protein, expressed by E. coli , with N-His labeled tag.
- Application
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别名
N-Syndecan; SDC3; SDCN; Syndecan-3; SYND3syndecan proteoglycan 3
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13277
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表达区间
M1-N289
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蛋白长度
Full Length
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分子量
37 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Syntaxin-3 is a member of the syntaxin family of proteins, which play a crucial role in the regulation of membrane fusion and synaptic transmission in neurons. It is primarily found in the presynaptic membranes of neurons, where it interacts with other proteins to facilitate the docking and fusion of synaptic vesicles with the plasma membrane, enabling the release of neurotransmitters. Abnormalities in Syntaxin-3 function have been implicated in various neurological disorders and diseases, such as autism spectrum disorders, schizophrenia, and neurodegenerative diseases. Research on recombinant Syntaxin-3 protein is imperative for understanding its structural and functional characteristics. Studies often focus on the protein's interactions with SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complexes and other synaptic proteins. By utilizing recombinant DNA technology, researchers can produce Syntaxin-3 in a controlled environment, allowing for detailed analysis of its biophysical properties, functional roles in neurotransmitter release, and interactions with other key proteins. This research not only provides insights into the molecular mechanisms underlying synaptic transmission but also holds potential therapeutic implications for restoring synaptic function in various neurological conditions. As a result, Syntaxin-3 serves as a significant target for advancing our understanding of synaptic physiology and its associated pathologies.
