Analytical Data
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Gene name
Syntaxin-3
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简介
Syntaxin-3 protein plays a potentially critical role in docking synaptic vesicles at the presynaptic zone, suggesting a role in regulating neurotransmitter release. Furthermore, it is also implicated as an apical receptor in apical vesicle membrane fusion, suggesting a broader involvement in intracellular trafficking. Syntaxin-3 Protein, Human (His) is the recombinant human-derived Syntaxin-3 protein, expressed by E. coli , with N-His labeled tag.
- Application
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Alternative Names
N-Syndecan; SDC3; SDCN; Syndecan-3; SYND3syndecan proteoglycan 3
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13277
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Expression Region
M1-N289
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Protein Length
Full Length
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Molecular Weight
37 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Syntaxin-3 is a member of the syntaxin family of proteins, which play a crucial role in the regulation of membrane fusion and synaptic transmission in neurons. It is primarily found in the presynaptic membranes of neurons, where it interacts with other proteins to facilitate the docking and fusion of synaptic vesicles with the plasma membrane, enabling the release of neurotransmitters. Abnormalities in Syntaxin-3 function have been implicated in various neurological disorders and diseases, such as autism spectrum disorders, schizophrenia, and neurodegenerative diseases. Research on recombinant Syntaxin-3 protein is imperative for understanding its structural and functional characteristics. Studies often focus on the protein's interactions with SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complexes and other synaptic proteins. By utilizing recombinant DNA technology, researchers can produce Syntaxin-3 in a controlled environment, allowing for detailed analysis of its biophysical properties, functional roles in neurotransmitter release, and interactions with other key proteins. This research not only provides insights into the molecular mechanisms underlying synaptic transmission but also holds potential therapeutic implications for restoring synaptic function in various neurological conditions. As a result, Syntaxin-3 serves as a significant target for advancing our understanding of synaptic physiology and its associated pathologies.
