Analytical Data
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Gene name
CREG1/CREG
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简介
CREG1/CREG is a potential regulator in transcriptional control that antagonizes adenovirus E1A-induced activation, emphasizing its role in regulating cell growth and differentiation. The glycosylation-dependent interaction with IGF2R highlights the multifaceted nature of CREG1/CREG in the molecular mechanisms governing transcriptional control. CREG1/CREG Protein, Mouse (HEK293, His) is the recombinant mouse-derived CREG1/CREG protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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Biological Activity
Measured by its binding ability in a functional ELISA. Immobilized IGF-II R at 2 μg/mL (100 μL/well) can bind Biotinylated CREG. The ED50 for this effect is 17.01 ng/mL. Measured by its binding ability in a functional ELISA. Immobilized IGF-II R at 2 μg/mL (100 μL/well) can bind Biotinylated CREG. The ED50 for this effect is 17.01 ng/mL.
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Alternative Names
rMuProtein CREG1/CREG, His; CREG1; cellular repressor of E1A-stimulated genes; cellular repressor of E1A-stimulated genes 1CREG; protein CREG1
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Species
Mouse
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
O88668
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Expression Region
R32-Q220
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AA Sequence
RGGRDHGDWDVDRRLPPLPPREDGPRVARFVTHVSDWGSLATISTIKEVRGWPFADIISISDGPPGEGTGEPYMYLSPLQQAVSDLQENPEATLTMSLAQTVYCRNHGFDPQSPLCVHIMMSGTVTKVNKTEEDYARDSLFVRHPEMKHWPSSHNWFFAKLKISRIWVLDYFGGPKVVTPEEYFNVTLQ
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Protein Length
Full Length of Mature Protein
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Molecular Weight
26-34 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CREG1, also known as CREG (Cellular Regulator of EGF), is a secreted protein that has garnered attention due to its role in various physiological and pathological processes. Initially identified for its involvement in cell proliferation and differentiation, CREG1 has since been implicated in tissue repair, inflammation, and cancer progression. Its expression is regulated by several growth factors and cytokines, suggesting its role as a modulator in cellular responses. The protein interacts with key pathways such as the EGF receptor signaling, influencing cellular behaviors critical for development and response to injury. Recent studies have highlighted the potential of CREG1 as a therapeutic target due to its dual role in promoting tissue regeneration while also participating in tumorigenesis. Moreover, research into the recombinant production of CREG1 aims to harness its biological functions for clinical applications, such as enhancing wound healing or developing anti-cancer therapies. As understanding of CREG1’s molecular mechanisms deepens, it holds promise for advancing regenerative medicine and oncology, making it a significant focus in current biomedical research.
