Analytical Data
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基因名
IL-27R beta
- Application
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别名
DIRS1; FNDC6; IL-20R2; Fibronectin Type III Domain Containing 6
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
> 90% as determined by SDS-PAGE.
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蛋白编号
Q6UXL0
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表达区间
Ala37~Glu290
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分子量
22/33kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IL-27R beta, also known as WSX-1, is a critical receptor component of the interleukin-27 (IL-27) signaling pathway, which plays a significant role in regulating immune responses. IL-27 is a cytokine produced by antigen-presenting cells, primarily involved in promoting Th1 cell differentiation and modulating various immune functions. Research has indicated that IL-27R beta is pivotal for the biological activities of IL-27, including its anti-inflammatory effects and its influence on T cell fate, which makes this receptor a potential target for therapeutic interventions in autoimmune diseases and chronic inflammatory conditions. Moreover, studies suggest that IL-27R beta may also have implications in cancer immunotherapy, as IL-27 can enhance anti-tumor immunity. Understanding the structure and function of IL-27R beta, alongside the mechanisms of its signaling pathways, can provide insights into its role in the immune system and inform the development of novel treatments for immune-related disorders. The generation of recombinant IL-27R beta protein facilitates these studies, enabling researchers to explore its interactions and biological functions in vitro and in vivo, thus contributing to our knowledge of host defense mechanisms and disease pathogenesis. The increasing interest in IL-27 signaling underscores the importance of IL-27R beta as a subject of investigation for improving therapeutic strategies targeting immune modulation.
