Analytical Data
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基因名
Annexin A13/ANXA13
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简介
Annexin A13/ANXA13 protein has a high affinity for folic acid and can bind to reduced folic acid derivatives to promote the transport of 5-methyltetrahydrofolate and folic acid analogs into cells. After endocytosis, the FOLR1 protein undergoes conformational changes when exposed to slightly acidic pH, resulting in a significant reduction in its affinity for folate and subsequent release. Annexin A13/ANXA13 Protein, Dog (P.pastoris, His) is the recombinant dog-derived Annexin A13/ANXA13 protein, expressed by P. pastoris , with N-His labeled tag.
- Application
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别名
ANXA13; ANX13Annexin A13; Annexin XIII; Annexin-13; Intestine-specific annexin; ISA
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种属
Dog
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表达系统
P. pastoris
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q29471-1
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表达区间
G2-H316
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氨基酸序列
GNRHAKAKSHHGFDVDHDAKKLNKACKGMGTDEAAIIEILSSRTSDERQQIKQKYKATYGKDLEEVFKSDLSGNFEKTALALLDRPSEYDARQLQKAMKGLGTDEAVLIEILCTRTNKEIMAIKEAYQRLFDRSLESDVKADTSGNLKAILVSLLQANRDEGDDVDKDLAGQDAKDLYDAGDGRWGTDELAFNEVLAKRSHKQLRATFQAYQILIDKDIEEAIEAETSGDLQKAYLTLVRCARDQEGYFADRLYKSMKGTGTDEETLIHIIVTRAEVDLQGIKAKFQEKYQKSLSDMVRSDTSGDFQKLLVALLH
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蛋白长度
Full Length of Isoform-1 Mature Protein
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Annexin A13 (ANXA13) is a member of the annexin family of proteins that exhibit calcium-dependent phospholipid binding, playing crucial roles in various cellular processes including membrane trafficking, cell signaling, and apoptosis. Initially identified in the human brain, ANXA13 has garnered interest due to its potential involvement in pathophysiological conditions such as cancer progression and neurodegenerative diseases. Unlike other annexins, ANXA13 has a unique structure and is characterized by a longer N-terminal domain, which may confer distinct functional properties. Recent studies suggest that ANXA13 might act as an important regulator of endocytosis and exocytosis, impacting cellular repair mechanisms and inflammatory responses. Given its diverse functions and implications in disease, the development of recombinant ANXA13 protein offers a valuable tool for elucidating its molecular mechanisms and interactions in cellular contexts. Research involving this recombinant protein can facilitate a deeper understanding of its role in physiological and pathological processes, potentially leading to new therapeutic strategies targeting ANXA13-related pathways.
