Analytical Data
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Gene name
KLRB1F/CD161f
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简介
The KLRB1F/CD161f protein is thought to bind CLEC2I/Clr-g, activate natural killer cells and provide costimulation for IL-2 production and T cell proliferation. This dual function highlights its critical role in coordinating immune responses. KLRB1F/CD161f Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived KLRB1F/CD161f protein, expressed by HEK293 , with N-hFc labeled tag.
- Application
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Alternative Names
Killer cell lectin-like receptor subfamily B member 1F; CD161f; Nkrp1f
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Species
Mouse
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Source
HEK293
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Tag
N-hFc
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q8VD98
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Expression Region
Q67-V217
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Protein Length
Extracellular Domain
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Molecular Weight
50-55 kDa.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KLRB1F/CD161f is a novel receptor belonging to the KLRB (Killer Cell Lectin-like Receptor B) family, playing a significant role in the immune response, particularly in natural killer (NK) cells and T cell activation. The research background for KLRB1F/CD161f focuses on its potential implications in immune regulation and its involvement in various diseases, including cancer and viral infections. Previous studies have highlighted the importance of KLRB family members in identifying and modulating immune cell interactions, making KLRB1F/CD161f an interesting target for therapeutic interventions. Understanding the structure, function, and signaling pathways associated with this receptor can reveal insights into immune mechanisms and aid in the development of novel immunotherapies. Investigating its ligand specificity and downstream effects on immune cell function could enhance our understanding of NK and T cell biology, ultimately contributing to more effective treatment strategies for immune-related conditions. This makes KLRB1F/CD161f a promising subject of research in the field of immunology and cancer therapy, with the potential to uncover new pathways for enhancing immune responses against tumors and pathogens.
