Analytical Data
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Gene name
VSTM1
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简介
VSTM1 interacts with S100A10 protein, inducing the dimerization of ANXA2/p36. This suggests a regulatory role in protein phosphorylation, with ANXA2 monomer being the preferred target for tyrosine-specific kinase in vitro. The resulting heterotetramer comprises two light chains of S100A10/p11 and two heavy chains of ANXA2/p36. Furthermore, VSTM1 engages with SCN10A and TASOR, indicating its participation in diverse molecular interactions. VSTM1 Protein, Human (119a.a, HEK293, His) is the recombinant human-derived VSTM1 protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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Alternative Names
V-set and transmembrane domain-containing protein 1; SIRL-1; Signal inhibitory receptor on leukocytes-1; VSTM1
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Species
Human
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6UX27
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Expression Region
Y17-T135
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Protein Length
Extracellular Domain
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Molecular Weight
25-35 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
VSTM1 (V-set and transmembrane domain containing 1) is a relatively novel protein that has garnered attention due to its potential roles in immune response and cell signaling. Research indicates that VSTM1 may be involved in the regulation of immune cell activation and differentiation, particularly in the context of T cells and other lymphocytes. Given its structure, comprising a V-set domain that suggests possible interactions with other proteins, VSTM1 is hypothesized to play a role in modulating immune responses, possibly acting as a co-stimulatory molecule or a receptor involved in lymphocyte interactions. Studies have shown its expression in various tissues, including those related to the immune system, though its exact biological functions remain largely unexplored. The investigation of VSTM1 as a recombinant protein offers significant insights into its functional capabilities, including potential applications in immunotherapy and vaccine development. Understanding the molecular mechanisms of VSTM1 could lead to advancements in therapeutic strategies for autoimmune diseases and cancers, where immune modulation is crucial. This research also emphasizes the importance of characterizing novel proteins to unveil their specific roles within complex biological systems. Overall, the study of VSTM1 represents a promising frontier in immunological research, with potential implications for enhancing immune responses and developing new treatment modalities.
