Analytical Data
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Gene name
HTRA1
- Application
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Alternative Names
High-temperature requirement A serine peptidase 1 (Serine protease 11) (Htra) (Prss11)
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Species
Mouse
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Source
E. coli
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Tag
C- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9R118
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Expression Region
141-480aa
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Molecular Weight
39.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
HTRA1 (high-temperature requirement A1) is a serine protease known for its role in various biological processes, including protein quality control, apoptosis, and cellular stress responses. The gene encoding HTRA1 has garnered significant attention due to its association with age-related diseases, particularly in the context of ocular health, such as age-related macular degeneration (AMD). Mutations and alterations in HTRA1 expression have been implicated in the pathogenesis of AMD, leading to degeneration of retinal pigment epithelial cells and vision loss. Additionally, HTRA1 has been shown to influence extracellular matrix remodeling and regulatory pathways, thereby playing a crucial role in the development of fibrotic diseases and certain cancers. Research on HTRA1 recombinant proteins aims to elucidate its functional mechanisms in both health and disease. By producing HTRA1 in a laboratory setting, scientists can investigate its proteolytic activity, interactions with various substrates, and overall impact on cellular homeostasis. This knowledge could pave the way for novel therapeutic strategies targeting HTRA1-related pathways, with potential implications for treating AMD and other related disorders. Thus, the study of HTRA1 recombinant protein not only advances our understanding of its biochemistry but also holds promise for developing interventions aimed at mitigating diseases linked to its dysfunction.
