Analytical Data
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基因名
Semaphorin-4C/SEMA4C
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简介
Semaphorin-4C/SEMA4C is the cell surface receptor of PLXNB2 and is critical for intercellular signaling.Semaphorin-4C/SEMA4C Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Semaphorin-4C/SEMA4C protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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别名
Semaphorin-4C; Semaphorin I; S4c; Semacl1; Semai; Sema I; Semaphorin-C-like 1; M-Sema F; Sema4c
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种属
Mouse
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表达系统
HEK293
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标签
C-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q64151
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表达区间
A21-G664
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氨基酸序列
AEMWWNLVPRKTVSSGELVTVVRRFSQTGIQDFLTLTLTEHSGLLYVGAREALFAFSVEALELQGAISWEAPAEKKIECTQKGKSNQTECFNFIRFLQPYNSSHLYVCGTYAFQPKCTYINMLTFTLDRAEFEDGKGKCPYDPAKGHTGLLVDGELYSATLNNFLGTEPVILRYMGTHHSIKTEYLAFWLNEPHFVGSAFVPESVGSFTGDDDKIYFFFSERAVEYDCYSEQVVARVARVCKGDMGGARTLQKKWTTFLKARLVCSAPDWKVYFNQLKAVHTLRGASWHNTTFFGVFQARWGDMDLSAVCEYQLEQIQQVFEGPYKEYSEQAQKWARYTDPVPSPRPGSCINNWHRDNGYTSSLELPDNTLNFIKKHPLMEDQVKPRLGRPLLVKKNTNFTHVVADRVPGLDGATYTVLFIGTGDGWLLKAVSLGPWIHMVEELQVFDQEPVESLVLSQSKKVLFAGSRSQLVQLSLADCTKYRFCVDCVLARDPYCAWNVNTSRCVATTSGRSGSFLVQHVANLDTSKMCNQYGIKKVRSIPKNITVVSGTDLVLPCHLSSNLAHAHWTFGSQDLPAEQPGSFLYDTGLQALVVMAAQSRHSGPYRCYSEEQGTRLAAESYLVAVVAGSSVTLEARAPLENLG
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蛋白长度
Extracellular Domain
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分子量
115-125 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Semaphorin-4C (SEMA4C) is a member of the semaphorin family, a group of proteins known for their roles in axon guidance, immune response, and tissue development. Research has identified SEMA4C as a critical player in various physiological and pathological processes, including neuronal development and cancer progression. Unlike its parental semaphorins, SEMA4C engages in both promoting and inhibiting cell signaling through interactions with its receptors, such as Plexin and Neuropilin. Its dual role has sparked interest in understanding how SEMA4C influences tumor microenvironments and immune modulation. Notably, SEMA4C's involvement in the regulation of immune cell activity suggests potential therapeutic applications in cancer immunotherapy. Recent studies have focused on the generation and characterization of recombinant SEMA4C proteins to facilitate the exploration of its biological functions and to develop SEMA4C-targeted treatments. By utilizing recombinant technology, researchers aim to elucidate the molecular mechanisms underlying SEMA4C's role in cell signaling pathways and to assess its therapeutic efficacy. Through these investigations, SEMA4C presents itself as a promising candidate for novel therapeutic interventions in cancer and immune disorders, highlighting the importance of further research into its structure-function relationships and clinical applications.
