Analytical Data
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Gene name
Semaphorin-4C/SEMA4C
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简介
Semaphorin-4C/SEMA4C is the cell surface receptor of PLXNB2 and is critical for intercellular signaling.Semaphorin-4C/SEMA4C Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Semaphorin-4C/SEMA4C protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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Alternative Names
Semaphorin-4C; Semaphorin I; S4c; Semacl1; Semai; Sema I; Semaphorin-C-like 1; M-Sema F; Sema4c
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Species
Mouse
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q64151
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Expression Region
A21-G664
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AA Sequence
AEMWWNLVPRKTVSSGELVTVVRRFSQTGIQDFLTLTLTEHSGLLYVGAREALFAFSVEALELQGAISWEAPAEKKIECTQKGKSNQTECFNFIRFLQPYNSSHLYVCGTYAFQPKCTYINMLTFTLDRAEFEDGKGKCPYDPAKGHTGLLVDGELYSATLNNFLGTEPVILRYMGTHHSIKTEYLAFWLNEPHFVGSAFVPESVGSFTGDDDKIYFFFSERAVEYDCYSEQVVARVARVCKGDMGGARTLQKKWTTFLKARLVCSAPDWKVYFNQLKAVHTLRGASWHNTTFFGVFQARWGDMDLSAVCEYQLEQIQQVFEGPYKEYSEQAQKWARYTDPVPSPRPGSCINNWHRDNGYTSSLELPDNTLNFIKKHPLMEDQVKPRLGRPLLVKKNTNFTHVVADRVPGLDGATYTVLFIGTGDGWLLKAVSLGPWIHMVEELQVFDQEPVESLVLSQSKKVLFAGSRSQLVQLSLADCTKYRFCVDCVLARDPYCAWNVNTSRCVATTSGRSGSFLVQHVANLDTSKMCNQYGIKKVRSIPKNITVVSGTDLVLPCHLSSNLAHAHWTFGSQDLPAEQPGSFLYDTGLQALVVMAAQSRHSGPYRCYSEEQGTRLAAESYLVAVVAGSSVTLEARAPLENLG
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Protein Length
Extracellular Domain
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Molecular Weight
115-125 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Semaphorin-4C (SEMA4C) is a member of the semaphorin family, a group of proteins known for their roles in axon guidance, immune response, and tissue development. Research has identified SEMA4C as a critical player in various physiological and pathological processes, including neuronal development and cancer progression. Unlike its parental semaphorins, SEMA4C engages in both promoting and inhibiting cell signaling through interactions with its receptors, such as Plexin and Neuropilin. Its dual role has sparked interest in understanding how SEMA4C influences tumor microenvironments and immune modulation. Notably, SEMA4C's involvement in the regulation of immune cell activity suggests potential therapeutic applications in cancer immunotherapy. Recent studies have focused on the generation and characterization of recombinant SEMA4C proteins to facilitate the exploration of its biological functions and to develop SEMA4C-targeted treatments. By utilizing recombinant technology, researchers aim to elucidate the molecular mechanisms underlying SEMA4C's role in cell signaling pathways and to assess its therapeutic efficacy. Through these investigations, SEMA4C presents itself as a promising candidate for novel therapeutic interventions in cancer and immune disorders, highlighting the importance of further research into its structure-function relationships and clinical applications.
