Analytical Data
-
Gene name
Dectin-2/CLEC6A
-
简介
The Dectin-2/CLEC6A protein is a calcium-dependent lectin, a pattern recognition receptor in the innate immune system that specifically binds to Candida albicans α-mannan. Dectin-2/CLEC6A Protein, Human (HEK293, Fc) is the recombinant human-derived Dectin-2/CLEC6A protein, expressed by HEK293 , with N-hFc labeled tag.
- Application
-
Alternative Names
C-type lectin domain family 6 member A; Dectin-2; Clec6a; Clec4n; Clecsf10
-
Species
Human
-
Source
HEK293
-
Tag
N-hFc
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q6EIG7-1
-
Expression Region
T42-L209
-
Protein Length
Extracellular Domain
-
Molecular Weight
52 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Dectin-2, also known as CLEC6A, is a C-type lectin receptor primarily expressed on dendritic cells and macrophages, playing a crucial role in the immune response against fungal infections. It recognizes specific carbohydrate structures on the surface of pathogens, facilitating the activation of innate immunity and promoting the secretion of pro-inflammatory cytokines. Recent studies have highlighted Dectin-2's involvement in modulating adaptive immune responses, particularly in the differentiation of T-helper cells. Researchers have been investigating recombinant Dectin-2/CLEC6A proteins to better understand their structure-function relationship and potential therapeutic applications. The use of recombinant proteins aids in elucidating the receptor's signaling pathways and interactions with pathogens, providing insights into immune modulation mechanisms. Furthermore, Dectin-2's role in the recognition of non-fungal pathogens has expanded its relevance in the field of immunology, making it a potential target for developing novel immunotherapies. The production of recombinant Dectin-2/CLEC6A also offers a platform for assessing its affinity for cytokines and other immune mediators, paving the way for innovative strategies in infectious disease management and vaccine development. Overall, the exploration of Dectin-2 as a research subject marks a significant advancement in our understanding of immune responses, with promising implications for clinical applications.
