Analytical Data
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基因名
Dectin-2/CLEC6A
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简介
The Dectin-2/CLEC6A protein is a calcium-dependent lectin, a pattern recognition receptor in the innate immune system that specifically binds to Candida albicans α-mannan. Dectin-2/CLEC6A Protein, Human (HEK293, Fc) is the recombinant human-derived Dectin-2/CLEC6A protein, expressed by HEK293 , with N-hFc labeled tag.
- Application
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别名
C-type lectin domain family 6 member A; Dectin-2; Clec6a; Clec4n; Clecsf10
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种属
Human
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表达系统
HEK293
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标签
N-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6EIG7-1
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表达区间
T42-L209
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蛋白长度
Extracellular Domain
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分子量
52 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Dectin-2, also known as CLEC6A, is a C-type lectin receptor primarily expressed on dendritic cells and macrophages, playing a crucial role in the immune response against fungal infections. It recognizes specific carbohydrate structures on the surface of pathogens, facilitating the activation of innate immunity and promoting the secretion of pro-inflammatory cytokines. Recent studies have highlighted Dectin-2's involvement in modulating adaptive immune responses, particularly in the differentiation of T-helper cells. Researchers have been investigating recombinant Dectin-2/CLEC6A proteins to better understand their structure-function relationship and potential therapeutic applications. The use of recombinant proteins aids in elucidating the receptor's signaling pathways and interactions with pathogens, providing insights into immune modulation mechanisms. Furthermore, Dectin-2's role in the recognition of non-fungal pathogens has expanded its relevance in the field of immunology, making it a potential target for developing novel immunotherapies. The production of recombinant Dectin-2/CLEC6A also offers a platform for assessing its affinity for cytokines and other immune mediators, paving the way for innovative strategies in infectious disease management and vaccine development. Overall, the exploration of Dectin-2 as a research subject marks a significant advancement in our understanding of immune responses, with promising implications for clinical applications.
