Analytical Data
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Gene name
PIN4
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简介
PIN4 isoform 1 functions as a ribosomal RNA processing factor in ribosome biogenesis and interacts with tightly bent AT-rich stretches of double-stranded DNA. Meanwhile, PIN4 isoform 2 specifically binds to double-stranded DNA. PIN4 Protein, Human (His) is the recombinant human-derived PIN4 protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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Alternative Names
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4; Parvulin-14; Parvulin-17; Peptidyl-prolyl cis-trans isomerase Pin4; Peptidyl-prolyl cis/trans isomerase EPVH; Rotamase Pin4; PIN4;
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Species
Human
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Source
E. coli
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Tag
N-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y237-2
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Expression Region
M1-K156
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Protein Length
Full Length of Isoform-2
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Molecular Weight
21 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PIN4, a member of the PIN family of auxin efflux carriers, plays a crucial role in plant development by regulating auxin distribution and flow. This protein is particularly important in the context of plant responses to environmental stimuli, as it influences processes such as root and shoot architecture, vascular differentiation, and overall plant growth. Recent studies have revealed that PIN4 is also involved in stress responses, enhancing the plant's ability to adapt to adverse conditions. Additionally, PIN4 has been identified as a key player in the establishment of polarity in plant tissues, contributing to the directional growth of cells. Understanding the molecular mechanisms underlying PIN4 function, including its interactions with other proteins and its regulatory pathways, is essential for advancing agricultural practices, particularly in improving crop resilience and productivity. Researchers are employing various techniques, such as genetic manipulation and biochemical assays, to investigate the structure and function of PIN4, aiming to unveil its precise role in auxin transport and signal transduction. This research holds potential implications for enhancing crop yield and quality, making it a significant area of study in plant molecular biology and biotechnology.
