Analytical Data
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基因名
PFDN4
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简介
The PFDN4 protein selectively binds to the cytoplasmic chaperone protein (c-CPN) and directs the protein for targeted transfer. It also interacts with nascent peptides and actively promotes correct folding in complex cellular environments. PFDN4 Protein, Human (His) is the recombinant human-derived PFDN4 protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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别名
Prefoldin Subunit 4; Protein C-1; PFDN4; PFD4
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种属
Human
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表达系统
E. coli
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标签
N-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NQP4
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表达区间
M1-S134
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蛋白长度
Full Length
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分子量
18-20 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PFDN4 (Prefoldin 4) is a member of the prefoldin family, which plays a crucial role in protein biogenesis by assisting in the proper folding of nascent polypeptides. It is particularly important in the assembly of multi-subunit protein complexes and in cellular responses to stress. Recent studies have implicated PFDN4 in various physiological processes, including those associated with the regulation of cell proliferation and differentiation. Dysregulation or mutations in the PFDN4 gene have been linked to several diseases, including certain cancers and neurodegenerative disorders, making it a focal point of research for understanding these conditions. Moreover, PFDN4's interaction with several molecular chaperones positions it as a key player in maintaining cellular homeostasis and protein integrity under stress conditions. The recombinant expression of PFDN4 in various systems provides valuable insights into its functional mechanisms and interactions with other proteins, thereby enhancing our understanding of its biological roles and potential therapeutic applications. As the study of PFDN4 continues to evolve, it holds promise for elucidating novel pathways in protein misfolding diseases and could lead to the development of new strategies for intervention and treatment.
