Analytical Data
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基因名
MDL-1/CLEC5A
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简介
CLEC5A/MDL-1 Protein positively regulates osteoclastogenesis and acts as a cell surface receptor signaling via TYROBP. Its expression relies on the TYROBP interaction and it plays a role in regulating inflammatory responses. CLEC5A/TYROBP/HCST complex formation highlights its intricate involvement in immune and inflammatory processes. CLEC5A/MDL-1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CLEC5A/MDL-1 protein, expressed by HEK293 , with N-hFc labeled tag.
- Application
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别名
MDL-1; CLECSF5; MDL1; CLEC5A; DAP12-associating lectin 1
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种属
Mouse
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表达系统
HEK293
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标签
N-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9R007-3
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表达区间
Y26-K190
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蛋白长度
Extracellular Domain
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分子量
64-68 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MDL-1, also known as CLEC5A, is a C-type lectin receptor that plays a significant role in the immune response, particularly in recognizing and responding to pathogens. Research has highlighted its involvement in various viral infections, including dengue and Zika viruses, where it mediates inflammatory responses and influences disease severity. Given its critical role in immune modulation, MDL-1/CLEC5A has emerged as a potential therapeutic target for treating viral infections and associated complications. Recombinant protein studies of MDL-1 aim to elucidate its structural and functional properties, which can provide insights into its mechanisms of action. By understanding how MDL-1 interacts with different ligands and immune cells, researchers hope to develop novel strategies for intervention in viral diseases. Furthermore, recombinant MDL-1 can serve as a valuable tool in vaccine development and immune profiling, paving the way for improved therapeutic approaches that harness the body’s natural defense mechanisms against viral pathogens. As such, the investigation of MDL-1/CLEC5A recombinant protein is crucial for advancing our understanding of immune regulation and developing innovative treatments for infectious diseases.
