Analytical Data
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基因名
PEA15
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简介
The PEA15 protein is a regulator of multiple cellular processes that blocks Ras-mediated integrin inhibition and modulates the ERK MAP kinase cascade. It inhibits RPS6KA3 activity by sequestering RPS6KA3 in the cytoplasm, regulating key cellular pathways. PEA15 Protein, Human is the recombinant human-derived PEA15 protein, expressed by E. coli , with tag free.
- Application
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别名
Astrocytic Phosphoprotein PEA-15; 15 kDa Phosphoprotein Enriched in Astrocytes; Phosphoprotein Enriched in Diabetes; PED; PEA15
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种属
Human
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q15121
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表达区间
M1-A130
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蛋白长度
Full Length
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分子量
12-16 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PEA15 (Phosphoprotein Enriched in Astrocytes 15) is a multifunctional protein originally identified in astrocytes, playing key roles in various cellular processes, including apoptosis, proliferation, and signaling pathways. Its involvement in cancer has garnered considerable attention, as PEA15 has been shown to modulate apoptosis and cellular growth, particularly in neuronal and glial cells. Research indicates that PEA15 interacts with several proteins, such as ERK1/2, and exerts regulatory effects on the MAPK signaling pathway, which is vital for cell survival and differentiation. Dysregulation of PEA15 has been implicated in tumorigenesis, making it a potential biomarker and therapeutic target in various cancers, including gliomas and breast cancer. Furthermore, PEA15's role in neurodegenerative diseases, such as Alzheimer's and Parkinson's, highlights its importance in understanding both cancer and neurobiology. The study of PEA15 is crucial for elucidating its mechanisms in oncogenesis and neuroprotection, providing insights into potential therapeutic strategies for diseases associated with its dysregulation. As research progresses, the recombinant expression of PEA15 in model systems is expected to unveil its functional dynamics and potentials in therapeutic applications.
