Analytical Data
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基因名
Bcl-XL
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简介
Bcl-XL protein forms heterodimers with BAX, BAK, or BCL2, but its antiapoptotic activity does not require heterodimerization with BAX. Bcl-XL Protein, Mouse (His) is the recombinant mouse-derived Bcl-XL protein, expressed by E. coli , with C-His labeled tag.
- Application
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别名
Bcl-2-like protein 1; Bcl2-L-1; Apoptosis regulator Bcl-X; Bclx
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种属
Mouse
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表达系统
E. coli
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标签
C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q64373-1
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表达区间
M1-R212
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氨基酸序列
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEETEAERETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIASWMATYLNDHLEPWIQENGGWDTFVDLYGNNAAAESRKGQERFNR
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蛋白长度
Partial
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分子量
33 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Bcl-XL, a member of the B-cell lymphocyte/leukemia-2 (Bcl-2) family, plays a critical role in regulating apoptosis, the process of programmed cell death. Its primary function is to promote cell survival by inhibiting the pro-apoptotic proteins, thereby controlling the balance between cell death and cell proliferation. Abnormal expression of Bcl-XL is implicated in various diseases, particularly in cancers where its overexpression can lead to resistance against chemotherapy and radiotherapy. This makes Bcl-XL a significant target for therapeutic interventions. Researchers have focused on producing recombinant Bcl-XL protein to better understand its structure, function, and interactions with other proteins. The availability of recombinant Bcl-XL allows for advanced studies on its role in the apoptotic pathway, the development of Bcl-XL inhibitors, and the design of novel cancer treatments aimed at restoring apoptosis in resistant cancer cells. Moreover, insights gained from these studies may facilitate the design of biomarker assays for cancer prognosis, ultimately contributing to more effective, personalized therapeutic strategies. The exploration of Bcl-XL through recombinant technology not only enhances our understanding of apoptosis but also paves the way for innovative approaches in the battle against cancer.
