Analytical Data
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Gene name
SGTA
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简介
SGTA proteins play a key role in promoting the release of oligosaccharides from the asparagine-linked glycoprotein peptide backbone by specifically targeting the GlcNAc-Asn bond. This enzymatic activity is essential for glycoprotein processing and maturation, contributing to post-translational modifications and protein quality control. SGTA Protein, Human (His) is the recombinant human-derived SGTA protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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Alternative Names
Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Alpha; Alpha-SGT; Vpu-Binding Protein; UBP; SGTA; SGT; SGT1
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Species
Human
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Source
E. coli
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Tag
N-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O43765
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Expression Region
M1-E313
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AA Sequence
MDNKKRLAYAIIQFLHDQLRHGGLSSDAQESLEVAIQCLETAFGVTVEDSDLALPQTLPEIFEAAATGKEMPQDLRSPARTPPSEEDSAEAERLKTEGNEQMKVENFEAAVHFYGKAIELNPANAVYFCNRAAAYSKLGNYAGAVQDCERAICIDPAYSKAYGRMGLALSSLNKHVEAVAYYKKALELDPDNETYKSNLKIAELKLREAPSPTGGVGSFDIAGLLNNPGFMSMASNLMNNPQIQQLMSGMISGGNNPLGTPGTSPSQNDLASLIQAGQQFAQQMQQQNPELIEQLRSQIRSRTPSASNDDQQE
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Protein Length
Full Length
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Molecular Weight
35 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of SGTA (Small Golgi Protein that Associates with Tetraspanin) recombinant proteins has gained significant interest in recent years due to their potential role in various cellular processes and diseases. SGTA is known to interact with tetraspanins, which are integral membrane proteins involved in organizing complexes within the cell membrane, playing crucial roles in cell adhesion, signaling, and migration. Research has shown that SGTA is implicated in essential functions such as protein trafficking and the regulation of cell surface receptors, contributing to the understanding of membrane dynamics and cell communication. Moreover, alterations in SGTA expression have been linked to several pathologies, including cancer, making it a relevant target for therapeutic exploration. By producing and characterizing SGTA recombinant proteins, researchers aim to elucidate the molecular mechanisms underlying SGTA's role in cellular contexts and its interaction with other proteins. This research not only aids in understanding fundamental biological processes but also holds promise for developing novel strategies in treating diseases associated with dysfunctional protein interactions.
