Analytical Data
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Gene name
Syntaxin-6
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简介
Syntaxin-6 is a SNARE protein that actively promotes vesicle movement to target membranes. Its involvement in retrograde transport is evident because it targets endosomes to the trans-Golgi network. Syntaxin-6 Protein, Human is the recombinant human-derived Syntaxin-6 protein, expressed by E. coli , with tag free.
- Application
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Alternative Names
Syntaxin-6; STX6
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Species
Human
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Source
E. coli
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O43752
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Expression Region
S2-Q234
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AA Sequence
SMEDPFFVVKGEVQKAVNTAQGLFQRWTELLQDPSTATREEIDWTTNELRNNLRSIEWDLEDLDETISIVEANPRKFNLDATELSIRKAFITSTRQVVRDMKDQMSTSSVQALAERKNRQALLGDSGSQNWSTGTTDKYGRLDRELQRANSHFIEEQQAQQQLIVEQQDEQLELVSGSIGVLKNMSQRIGGELEEQAVMLEDFSHELESTQSRLDNVMKKLAKVSHMTSDRRQ
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Protein Length
Partial
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Molecular Weight
32.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Syntaxin-6 is a member of the syntaxin family of proteins, which are integral components of the synaptic vesicle recycling machinery in neurons and are essential for membrane fusion processes. Its role extends beyond the nervous system, influencing intracellular trafficking and exocytosis in various cell types. Research into Syntaxin-6 has gained momentum due to its involvement in various cellular functions, including the regulation of neurotransmitter release and the transport of proteins to their designated locations within the cell. Dysregulation or mutations in Syntaxin-6 have been associated with several diseases, including neurodegenerative disorders and certain types of cancer, highlighting its potential as a therapeutic target. Recombination and expression of Syntaxin-6 proteins in model systems allow for detailed studies of its structural and functional properties, enabling the elucidation of its precise role in membrane fusion dynamics. Moreover, understanding the molecular mechanisms by which Syntaxin-6 interacts with other proteins in the SNARE complex is crucial for unraveling the complexities of vesicular transport. Ongoing studies employing advanced imaging techniques and biochemical assays are aimed at revealing the mechanistic details of Syntaxin-6, potentially opening avenues for therapeutic interventions in diseases linked to synaptic dysfunction and transport anomalies. This makes the investigation of Syntaxin-6 not only a significant aspect of cellular biology but also a promising field for therapeutic exploration.
