Analytical Data
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Gene name
ZNHIT1
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简介
ZNHIT1 is a key chromatin remodeling protein that regulates gene expression by promoting the incorporation of histone variants H2AZ1/H2A.Z. In muscle differentiation, ZNHIT1 is recruited to the MYOG promoter, mediating H2AZ1 binding and inducing muscle-specific gene expression. ZNHIT1 Protein, Human (His) is the recombinant human-derived ZNHIT1 protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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Alternative Names
inc finger HIT domain-containing protein 1; cyclin-G1-binding protein 1; zinc finger protein subfamily 4A member 1; p18 hamlet; CGBP1; ZNFN4A1; ZNHIT1
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Species
Human
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Source
E. coli
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Tag
N-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O43257
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Expression Region
M1-V154
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Protein Length
Full Length
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Molecular Weight
21 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ZNHIT1 (Zinc Finger HIT-Type Containing 1) is a protein that has garnered significant interest due to its potential roles in various biological processes, including cell proliferation, differentiation, and apoptosis. Initially identified as a zinc finger protein, ZNHIT1 is thought to be involved in transcriptional regulation. Recent studies have indicated its possible implications in cancer biology, particularly in how it may influence tumor progression and response to therapy. The interest in ZNHIT1 has been further fueled by evidence suggesting that its expression levels correlate with the prognosis of certain cancers, making it a potential biomarker for disease outcome. In addition, ZNHIT1 has been implicated in the regulation of immune responses, further expanding its relevance in both cancer and autoimmune diseases. Exploring the functional mechanisms of ZNHIT1 through recombinant protein studies can elucidate its effects on cellular pathways and potentially identify it as a therapeutic target. With advances in protein engineering and expression systems, researchers aim to produce recombinant ZNHIT1 to facilitate detailed biochemical and structural analyses. This research may provide valuable insights into its functional role and pave the way for innovative treatment strategies targeting ZNHIT1 in various diseases.
