Analytical Data
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Gene name
CLEC2D
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简介
The OCIL/CLEC2D protein acts as a receptor for KLRB1 and protects target cells from natural killer cell-mediated lysis. It not only inhibits osteoclast formation and bone resorption, but also regulates the release of interferon-γ, indicating that it has immune and bone-related regulatory functions. OCIL/CLEC2D Protein, Human (HEK293, Fc-Avi) is the recombinant human-derived OCIL/CLEC2D protein, expressed by HEK293 , with N-hFc, N-Avi labeled tag.
- Application
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Alternative Names
C-type lectin domain family 2 member D; Lectin-like NK cell receptor; Lectin-like transcript 1; LLT-1; CLAX; LLT1; OCIL; CLEC2D
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Species
Human
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Source
HEK293
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Tag
N-hFc;N-Avi
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UHP7-1
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Expression Region
R60-V191
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Protein Length
Extracellular Domain
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Molecular Weight
68-78 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CLEC2D is a member of the C-type lectin receptor family, which plays a crucial role in immune responses and cell signaling. Recent studies have highlighted its importance in various biological processes, including the regulation of dendritic cell function and T cell activation. Research indicates that CLEC2D is involved in mediating interactions between immune cells and pathogens, influencing both adaptive and innate immunity. Its unique structure, characterized by a carbohydrate recognition domain, allows it to bind specific glycoconjugates on the surface of pathogens, which is essential for initiating immune responses. Given its pivotal role in the immune system, CLEC2D is considered a potential target for therapeutic interventions in autoimmune diseases, infections, and cancer. Understanding the structure-function relationship of CLEC2D through advanced techniques like X-ray crystallography and molecular modeling is critical for designing novel drugs that can modulate its activity. Continued research into CLEC2D will not only enhance our knowledge of immune regulation but also pave the way for innovative strategies in immunotherapy and vaccine development, making it a significant focus in current biomedical research.
