Analytical Data
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基因名
HSPB11
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简介
The HSPB11 protein is an important component of IFT complex B and is indispensable for sonic eager/SHH signaling. It promotes intraflagellar transport in ciliated tissues such as kidney and testis, mediating the transport of SHH components. HSPB11 Protein, Human (His) is the recombinant human-derived HSPB11 protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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别名
Heat Shock Protein Beta-11; Hspb11; Placental Protein 25; PP25; HSPB11; C1orf41
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种属
Human
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表达系统
E. coli
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标签
N-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y547
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表达区间
M1-S144
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蛋白长度
Full Length
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分子量
21 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HSPB11, a member of the HSPB (heat shock protein beta) family, is a small heat shock protein that plays a significant role in cellular stress responses, particularly during proteotoxic stress. It is expressed in various tissues and is associated with neuroprotective and cytoprotective functions, making it a focal point in the research of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and Charcot-Marie-Tooth disease. Recent studies suggest that HSPB11 contributes to the maintenance of cellular proteostasis by stabilizing partially folded proteins and preventing their aggregation, which is critical for neuronal health. The interest in HSPB11 also stems from its potential therapeutic applications, as enhancing its expression or function might offer a protective effect against pathological protein aggregation. Recombinant HSPB11 protein has been produced to better understand its structural properties and functional mechanisms. This recombinant approach allows researchers to investigate its chaperone activity, interactions with other cellular proteins, and impact on cellular pathways under stress conditions. Understanding HSPB11's role in cellular homeostasis could lead to novel interventions for diseases characterized by protein misfolding and aggregation, thus highlighting its importance in both basic and translational research.
