Analytical Data
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Gene name
HSPB11
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简介
The HSPB11 protein is an important component of IFT complex B and is indispensable for sonic eager/SHH signaling. It promotes intraflagellar transport in ciliated tissues such as kidney and testis, mediating the transport of SHH components. HSPB11 Protein, Human (His) is the recombinant human-derived HSPB11 protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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Alternative Names
Heat Shock Protein Beta-11; Hspb11; Placental Protein 25; PP25; HSPB11; C1orf41
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Species
Human
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Source
E. coli
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Tag
N-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y547
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Expression Region
M1-S144
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Protein Length
Full Length
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Molecular Weight
21 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HSPB11, a member of the HSPB (heat shock protein beta) family, is a small heat shock protein that plays a significant role in cellular stress responses, particularly during proteotoxic stress. It is expressed in various tissues and is associated with neuroprotective and cytoprotective functions, making it a focal point in the research of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and Charcot-Marie-Tooth disease. Recent studies suggest that HSPB11 contributes to the maintenance of cellular proteostasis by stabilizing partially folded proteins and preventing their aggregation, which is critical for neuronal health. The interest in HSPB11 also stems from its potential therapeutic applications, as enhancing its expression or function might offer a protective effect against pathological protein aggregation. Recombinant HSPB11 protein has been produced to better understand its structural properties and functional mechanisms. This recombinant approach allows researchers to investigate its chaperone activity, interactions with other cellular proteins, and impact on cellular pathways under stress conditions. Understanding HSPB11's role in cellular homeostasis could lead to novel interventions for diseases characterized by protein misfolding and aggregation, thus highlighting its importance in both basic and translational research.
