Analytical Data
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基因名
IL-21R beta
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简介
IL-20R beta Protein (IL20RB) is the beta subunit of IL-20 receptor, forms functional heterodimers with different subunit protein and involves in STAT3 activation pathway[1]. The IL-20RA/IL-20RB dimer is a receptor for IL-19, IL-20 and IL-24. The IL-22RA1/IL-20RB dimer is a receptor for IL-20 and IL-24[2]. IL-20R beta Protein, Human (HEK293, Fc) is produced in HEK293 cells with a C-Terminal hFc-tag.
- Application
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别名
Interleukin-20 receptor subunit beta; IL-20R-beta; IL-20RB; FNDC6; IL-20R2; DIRS1
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种属
Mouse
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表达系统
HEK293
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标签
C-His
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纯度
> 90% as determined by SDS-PAGE.
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蛋白编号
E9Q9A6
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表达区间
V27-S225
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蛋白长度
Partial
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分子量
23.8 kDa.
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interleukin-21 receptor (IL-21R) is a critical component of the immune system, playing a vital role in regulating immune responses, especially in T and B cell functions. It is primarily expressed on various immune cells, including T cells, B cells, and natural killer (NK) cells. The IL-21/IL-21R signaling pathway has garnered substantial interest due to its implications in numerous physiological processes and disease states, including autoimmune diseases, infections, and cancers. Understanding the structural and functional aspects of IL-21R is crucial for developing therapeutic interventions targeting immunological disorders. Recent advances in recombinant protein technology have enabled researchers to efficiently produce IL-21R beta (the functional subunit of the receptor) for in-depth studies. Recombinant IL-21R beta can be used in various applications, such as elucidating the receptor's signaling mechanisms, characterizing its interaction with IL-21, and evaluating its potential as a target for monoclonal antibody therapy. Additionally, studying this protein helps in understanding its role in modulating immune responses, which is essential for devising strategies to enhance or inhibit immune functions in various diseases. The research surrounding IL-21R beta is pivotal, as it opens avenues for novel therapeutic designs aimed at manipulating immune responses for better clinical outcomes.
