Analytical Data
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Gene name
IL-21R beta
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简介
IL-20R beta Protein (IL20RB) is the beta subunit of IL-20 receptor, forms functional heterodimers with different subunit protein and involves in STAT3 activation pathway[1]. The IL-20RA/IL-20RB dimer is a receptor for IL-19, IL-20 and IL-24. The IL-22RA1/IL-20RB dimer is a receptor for IL-20 and IL-24[2]. IL-20R beta Protein, Human (HEK293, Fc) is produced in HEK293 cells with a C-Terminal hFc-tag.
- Application
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Alternative Names
Interleukin-20 receptor subunit beta; IL-20R-beta; IL-20RB; FNDC6; IL-20R2; DIRS1
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Species
Mouse
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Source
HEK293
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Tag
C-His
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Purity
> 90% as determined by SDS-PAGE.
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Uniprot
E9Q9A6
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Expression Region
V27-S225
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Protein Length
Partial
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Molecular Weight
23.8 kDa.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Interleukin-21 receptor (IL-21R) is a critical component of the immune system, playing a vital role in regulating immune responses, especially in T and B cell functions. It is primarily expressed on various immune cells, including T cells, B cells, and natural killer (NK) cells. The IL-21/IL-21R signaling pathway has garnered substantial interest due to its implications in numerous physiological processes and disease states, including autoimmune diseases, infections, and cancers. Understanding the structural and functional aspects of IL-21R is crucial for developing therapeutic interventions targeting immunological disorders. Recent advances in recombinant protein technology have enabled researchers to efficiently produce IL-21R beta (the functional subunit of the receptor) for in-depth studies. Recombinant IL-21R beta can be used in various applications, such as elucidating the receptor's signaling mechanisms, characterizing its interaction with IL-21, and evaluating its potential as a target for monoclonal antibody therapy. Additionally, studying this protein helps in understanding its role in modulating immune responses, which is essential for devising strategies to enhance or inhibit immune functions in various diseases. The research surrounding IL-21R beta is pivotal, as it opens avenues for novel therapeutic designs aimed at manipulating immune responses for better clinical outcomes.
