Analytical Data
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Gene name
LRRC25
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简介
The LRRC25 protein is an important regulator that inhibits RLR-mediated type I interferon signaling by coordinating the autophagic degradation of RIGI. Its specific interaction with ISG15-related RIGI promotes binding to p62/SQSTM1, leading to selective autophagic RIGI degradation. LRRC25 Protein, Human (HEK293, His) is the recombinant human-derived LRRC25 protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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Alternative Names
Leucine-rich repeat-containing protein 25; Monocyte and plasmacytoid-activated protein; MAPA; FLJ38116; UNQ6169/PRO20174
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Species
Human
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N386
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Expression Region
L21-T165
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Protein Length
Extracellular Domain
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Molecular Weight
20-40 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LRRC25 (Leucine-rich repeat-containing protein 25) is a member of the leucine-rich repeat protein family and has garnered attention in recent years for its potential implications in various biological processes and diseases. Research has indicated that LRRC25 may play a significant role in immune regulation, particularly in T cell activation and differentiation. Its expression patterns suggest involvement in hematopoiesis and immune responses. Understanding the structure and function of LRRC25 is essential for elucidating its role in immune system disorders, including autoimmune diseases and cancers. Additionally, the development of recombinant LRRC25 protein provides a valuable tool for investigating its biological functions and interactions with other cellular components. Studies utilizing recombinant protein can help clarify the mechanisms through which LRRC25 influences immune cell behavior and signal transduction pathways. This research not only enhances our comprehension of LRRC25's role in health and disease but also opens avenues for therapeutic innovations targeting LRRC25-related pathways. Given the growing interest in immune modulation as a therapeutic strategy, further exploration of LRRC25 and its recombinant forms is poised to yield significant insights into its functional relevance in immunology and potential as a biomarker or therapeutic target.
