Analytical Data
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基因名
HSF2
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简介
As a DNA-binding protein, HSF2 protein has specific affinity for the heat shock promoter element (HSE), thereby activating transcription. Notably, in higher eukaryotes, the ability of HSF2 to bind to HSE depends on the exposure of cells to heat shock. HSF2 Protein, Human (His) is the recombinant human-derived HSF2 protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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别名
rHuHeat shock factor protein 2/HSF2, His; Heat Shock Factor Protein 2; HSF 2; Heat Shock Transcription Factor 2; HSTF 2; HSF2; HSTF2
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种属
Human
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表达系统
E. coli
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标签
N-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q03933
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表达区间
S411-S536
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蛋白长度
Partial
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分子量
26 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HSF2, or Heat Shock Factor 2, is a critical transcription factor that plays a vital role in the cellular response to stress, particularly thermal and oxidative stress. It is part of the heat shock protein (HSP) family, which is essential for protein folding, protection against misfolded proteins, and ensuring cellular homeostasis. Unlike HSF1, which mediates the primary heat shock response, HSF2 is implicated in the regulation of HSP genes during specific developmental stages and under various stress conditions, suggesting a nuanced role in cellular adaptation. Recent research has highlighted HSF2's involvement in diverse biological processes, including cell differentiation, apoptosis, and neuroprotection, linking it to diseases such as cancer and neurodegenerative disorders. The recombinant expression of HSF2 enables detailed studies of its functional mechanisms at the molecular level, facilitating the exploration of its potential as a therapeutic target. Characterizing HSF2 through recombinant protein studies can provide deeper insights into its regulatory networks and interactions with other cellular components, thus advancing our understanding of stress response pathways and their implications in health and disease.
