Analytical Data
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Gene name
HSF2
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简介
As a DNA-binding protein, HSF2 protein has specific affinity for the heat shock promoter element (HSE), thereby activating transcription. Notably, in higher eukaryotes, the ability of HSF2 to bind to HSE depends on the exposure of cells to heat shock. HSF2 Protein, Human (His) is the recombinant human-derived HSF2 protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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Alternative Names
rHuHeat shock factor protein 2/HSF2, His; Heat Shock Factor Protein 2; HSF 2; Heat Shock Transcription Factor 2; HSTF 2; HSF2; HSTF2
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Species
Human
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Source
E. coli
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Tag
N-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q03933
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Expression Region
S411-S536
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Protein Length
Partial
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Molecular Weight
26 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HSF2, or Heat Shock Factor 2, is a critical transcription factor that plays a vital role in the cellular response to stress, particularly thermal and oxidative stress. It is part of the heat shock protein (HSP) family, which is essential for protein folding, protection against misfolded proteins, and ensuring cellular homeostasis. Unlike HSF1, which mediates the primary heat shock response, HSF2 is implicated in the regulation of HSP genes during specific developmental stages and under various stress conditions, suggesting a nuanced role in cellular adaptation. Recent research has highlighted HSF2's involvement in diverse biological processes, including cell differentiation, apoptosis, and neuroprotection, linking it to diseases such as cancer and neurodegenerative disorders. The recombinant expression of HSF2 enables detailed studies of its functional mechanisms at the molecular level, facilitating the exploration of its potential as a therapeutic target. Characterizing HSF2 through recombinant protein studies can provide deeper insights into its regulatory networks and interactions with other cellular components, thus advancing our understanding of stress response pathways and their implications in health and disease.
