Analytical Data
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基因名
Claudin-4/CLDN4 Protein-VLP
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简介
Claudin-4/CLDN4 Protein-VLP, Human (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.
- Application
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别名
CLDN4; claudin 4; CPETR, CPETR1; claudin-4; Clostridium perfringens enterotoxin receptor 1; CPE R; hCPE R; WBSCR8; Williams Beuren syndrome chromosomal region 8 protein;
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种属
Human
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表达系统
HEK293
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标签
C-10*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O14493
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表达区间
M1-V209
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氨基酸序列
MASMGLQVMGIALAVLGWLAVMLCCALPMWRVTAFIGSNIVTSQTIWEGLWMNCVVQSTGQMQCKVYDSLLALPQDLQAARALVIISIIVAALGVLLSVVGGKCTNCLEDESAKAKTMIVAGVVFLLAGLMVIVPVSWTAHNIIQDFYNPLVASGQKREMGASLYVGWAASGLLLLGGGLLCCNCPPRTDKPYSAKYSAARSAAASNYV
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蛋白长度
Full Length
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分子量
23.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Claudin-4 (CLDN4) is a critical tight junction protein that plays a significant role in maintaining epithelial barrier integrity and regulating paracellular permeability. It is highly expressed in various tissues, including the gastrointestinal tract and pancreatic cells, and has been implicated in several diseases, including cancer. In particular, CLDN4 is of interest due to its upregulation in pancreatic ductal adenocarcinoma, making it a potential target for therapeutic intervention and diagnostic applications. The use of Virus-Like Particle (VLP) technology to produce recombinant proteins has gained attention for its ability to mimic natural viruses while being non-infectious. VLPs can present multiple copies of a target protein on their surface, enhancing immune responses and facilitating the study of protein interactions and functions. Research on CLDN4/CLDN4 Protein-VLP aims to leverage this technology for developing efficient vaccines or immunotherapeutics against cancers with CLDN4 overexpression. Additionally, VLPs offer a valuable platform for investigating the structure and function of CLDN4 in a controlled environment, aiding in the understanding of its role in cellular processes and pathogenesis. The combination of CLDN4 research with VLP technology holds promise for both therapeutic and diagnostic advancements, potentially leading to improved management strategies for diseases associated with altered CLDN4 expression.
