Analytical Data
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Gene name
IL-23R
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简介
IL-23R protein and IL12RB1 form interleukin 23 receptor, which is the key binding site of IL23. IL-23R mediates stimulation of T cells, NK cells, and possibly macrophages/myeloid cells, activating the Jak-Stat signaling cascade. IL-23R Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived IL-23R protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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Biological Activity
Measured by its binding ability in a functional ELISA. When Recombinant Mouse IL-23R is present at 5 μg/mL, can bind Recombinant Mouse IL-23 Protein. The ED50 for this effect is 20.81 ng/mL. Measured by its binding ability in a functional ELISA. When Recombinant Mouse IL-23R is present at 5 μg/mL, can bind Recombinant Mouse IL-23 Protein .The ED50 for this effect is 20.81 ng/mL.
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Alternative Names
Interleukin-23 receptor; Il23r; IL-23 receptor
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Species
Mouse
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 95% as determined by reducing SDS-PAGE. as determined by SDS-PAGE.
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Uniprot
Q8K4B4
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Expression Region
G24-D372
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AA Sequence
GITSINCSGDMWVEPGEIFQMGMNVSIYCQEALKHCRPRNLYFYKNGFKEEFDITRINRTTARIWYKGFSEPHAYMHCTAECPGHFQETLICGKDISSGHPPDAPSNLTCVIYEYSGNMTCTWNTGKPTYIDTKYIVHVKSLETEEEQQYLASSYVKISTDSLQGSRKYLVWVQAVNSLGMENSQQLHVHLDDIVIPSASIISRAETTNDTVPKTIVYWKSKTMIEKVFCEMRYKTTTNQTWSVKEFDANFTYVQQSEFYLEPDSKYVFQVRCQETGKRNWQPWSSPFVHQTSQETGKRNWQPWSSPFVHQTSQTVSQVTAKSSHEPQKMEMLSATIFRGHPASGNHQD
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Protein Length
Extracellular Domain
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Molecular Weight
90-110 kDa.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Related Products
Protein Description
Interleukin-23 receptor (IL-23R) plays a crucial role in the immunological pathways associated with various inflammatory and autoimmune diseases, including psoriasis, inflammatory bowel disease (IBD), and rheumatoid arthritis. This receptor is a key component of the IL-23 signaling pathway, which is essential for the differentiation and survival of Th17 cells, a subset of T helper cells that produce pro-inflammatory cytokines. Given the importance of IL-23R in mediating inflammatory responses, it has emerged as a significant therapeutic target. Recombinant proteins of IL-23R are employed in research to study its structure, function, and interaction with ligands, as well as to develop potential inhibitors that could lead to novel treatment options for diseases driven by Th17 responses. By utilizing advanced techniques such as protein engineering and cell line production, researchers aim to create recombinant IL-23R that can be used for further biochemical and pharmacological studies. This research not only enhances the understanding of IL-23R signaling mechanisms but also paves the way for the development of biologic therapies that can specifically modulate this pathway, ultimately improving clinical outcomes for patients suffering from autoimmune conditions.
