Analytical Data
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基因名
DKK-1
- Application
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别名
SK; Dickkopf Homolog 2(Xenopus Laevis)
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O94907
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表达区间
33-266aa
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分子量
29.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DKK-1 (Dickkopf-related protein 1) is a secreted glycoprotein that plays a crucial role in the regulation of Wnt signaling, a pathway important for various developmental processes and tissue homeostasis. Dysregulation of DKK-1 has been implicated in several pathological conditions, including cancer, osteoporosis, and cardiovascular diseases. In cancer, elevated levels of DKK-1 can promote tumor progression by inhibiting apoptosis in cancer cells and facilitating the creation of a favorable microenvironment for tumor growth. In the context of bone diseases, DKK-1 acts as a negative regulator of osteogenesis, and its overexpression can lead to impaired bone formation, making it a prime target for therapeutic interventions. Researchers are now focusing on developing recombinant DKK-1 proteins to study its biological functions and interactions with other signaling pathways. These studies aim to elucidate the molecular mechanisms underlying DKK-1's role in various diseases and to explore its potential as a biomarker for disease progression or as a therapeutic target. Understanding DKK-1's complex biology may offer new insights for treating disorders associated with Wnt signaling dysregulation, paving the way for innovative treatment strategies in regenerative medicine and oncology.
